Revista de Odontologia da UNESP
https://revodontolunesp.com.br/article/588018cb7f8c9d0a098b4e13
Revista de Odontologia da UNESP
Review Article

Genetic polymorphism associated with periodontal disease in Brazilians: systematic review

Polimorfismo genético associado à doença periodontal na população brasileira: revisão de literatura

Hoçoya, Luciana Satie; Jardini, Maria Aparecida Neves

Rev. odontol. UNESP, vol.39, n5, p.305-310, 2010
PDF
Downloads: 8
Views: 1138

Abstract

Genetic factor has been the focus of research as a modifier in the development of periodontal disease.  Because of the ethnic influence in the genetic load, the studies can not be the same in all populations. In Brazil, studies are being developed in order to try to involve the genetic markers with periodontal disease. The purpose of this review was to assess which genetic polymorphisms are associated to periodontal disease, chronic and aggressive forms, in Brazilian population. Bank data consulted was Pubmed and articles were selected between the years 2003 and 2010. Among the studies, the association between the genetic polymorphisms and chronic periodontitis were found in: IL-1β (+3954), IL-1A (-889), IL-6 (-174), IL-10 in lócus -819 e -592, MMP -1 promoter, MMP-3 (-1612) and VRD (Taql/Bsml). In studies with IL-4 (-590, íntron 2), MMP-1 (-1607, -519), IL-8 (rs 4073), IL-10 (-1087) and TNFA (-308) no relationship with chronic periodontitis were found. For the aggressive form of periodontal disease studies have shown associations for Fcγ RIIa e Fcγ RIIIb receptors and gene 5-HTT. For the aggressive form of the disease the association were not present in polymorphisms of IL-1β (+3954), IL-1A (-889) and TNFA (-308). Based on those results, it is concluded that more studies should be conducted. These markers can conduct us to plan a better treatment.

Keywords

Periodontal diseases, genetic polymorphism, population

Resumo

O fator genético tem sido foco de pesquisas como modificador do desenvolvimento da doença periodontal. Pelo fato da etnia influenciar a carga genética, os estudos não podem ser extrapolados para todas as populações. No Brasil, estudos vêm sendo desenvolvidos a fim de tentar associar os marcadores genéticos com a doença periodontal. O objetivo deste estudo foi conduzir uma revisão da literatura para investigar os polimorfismos genéticos associados à doença periodontal na população brasileira. A base de dados consultada foi Pubmed e foram selecionados artigos do período de 2003 a 2010. Os trabalhos que avaliaram a periodontite crônica encontraram associações para os seguintes polimorfismos genéticos: IL-1 β (+3954), IL-1A (-889), IL-6 (-174), IL-10 nos lócus -819 e -592, região promotora de  matriz metaloproteinase-1, MMP-3 (-1612) e VRD (Taql/Bsml). Nos estudos com IL-4 (-590 e intron 2), MMP -1 (-1607 e -519), IL-8 (rs 4073), IL-10 (-1087) e TNFA (-308) as associações relacionadas à doença periodontal crônica não ocorreram. Em relação à doença periodontal agressiva, foram encontrados resultados positivos para as associações nos polimorfismos dos receptores de imunoglobina Fcγ RIIa e Fcγ RIIIb e gene 5-HTT. Não foram encontradas associações com polimorfismos IL-1β (+3954), IL-1A (-889) e TNFA (-308). Mais estudos devem ser realizados na população brasileira para que sejam determinados os marcadores genéticos que influenciam o curso da doença periodontal. Estes marcadores poderão atuar como indicadores de prognóstico e auxiliar no planejamento e numa melhor conduta de tratamento.

Palavras-chave

Doenças periodontais, polimorfismo genético, população

References

 


1. Loe H, Theilade E, Jensen SB. Experimental gingivitis in man. J Periodontol. 1965; 36: 177-87.

2. Page RC, Kornman KS. The pathogenesis of human periodontitis: an introduction. Periodontol 2000. 1997; 14: 9-11.

3. Tonetti MS, Claffey N. Advances in the progression of periodontitis and proposal of definitions of a periodontitis case and disease progression for use in risk factor research. Group C consensus report of the 5th European Workshop in Periodontology. J Clin Periodontol. 2005; 32(Suppl 6): 210-3.

4. Moreira PR, Costa JE, Gomez RS, Gollob KJ, Dutra WO. The IL1A (-889) gene polymorphism is associated with chronic periodontal disease in a sample of Brazilian individuals. J Periodontal Res. 2007; 42: 23-30.

5. Pontes CC, Gonzales JR, Novaes AB Jr, Taba Junior M, Grisi MF, Michel J, et al. ‘Interleukin-4 gene polymorphism and its relation to periodontal disease in a Brazilian population of African heritage’. J Dent. 2004; 32: 241-6.

6. Astolfi CM, Shinohara AL, da Silva RA, Santos MC, Line SR, de Souza AP. Genetic polymorphisms in the MMP-1 and MMP-3 gene may contribute to chronic periodontitis in a Brazilian population. J Clin Periodontol. 2006; 33: 699-703.

7. Strachan T RA. Genética molecular humana. 2a ed. Porto Alegre: Art Med; 2002.

8. Taylor JJ, Preshaw PM, Donaldson PT. Cytokine gene polymorphism and immunoregulation in periodontal disease. Periodontol 2000. 2004; 35: 158-82.

9. Lewin B. Genes VII. Porto Alegre: Art Med; 2001.

10. Kornman KS, di Giovine FS. Genetic variations in cytokine expression: a risk factor for severity of adult periodontitis. Ann Periodontol. 1998; 3: 327-38.

11. Kornman KS, Crane A, Wang HY, di Giovine FS, Newman MG, Pirk FW, et al. The interleukin-1 genotype as a severity factor in adult periodontal disease. J Clin Periodontol. 1997; 24: 72-7.

12. Auron PE, Webb AC. Interleukin-1: a gene expression system regulated at multiple levels. Eur Cytokine Netw. 1994; 5: 573-92.

13. Birkedal-Hansen H. Role of cytokines and inflammatory mediators in tissue destruction. J Periodontal Res. 1993; 28: 500-10.

14. Freitas NM. Avaliação da associação entre o polimorfismo dos genes IL-1A (-889), IL-1B (-511), IL-1B (+3954), IL-1RN (íntron 2 VNTR) e TNFA (-308) e a periodontite agressiva [tese doutorado]. São Paulo: Faculdade de Odontologia da USP; 2007.

15. Moreira PR, de Sa AR, Xavier GM, Costa JE, Gomez RS, Gollob KJ, et al. A functional interleukin-1 beta gene polymorphism is associated with chronic periodontitis in a sample of Brazilian individuals. J Periodontal Res. 2005; 40: 306-11.

16. de Brito Júnior RB, Trombone APF, Repeke CE, Cardoso CR, Jr. WM, Santos CF, et al. An Interleukin 1β (1L-1β) single-nucleotide polymorphism at position 3954 and red complex periodontopathogens independently and additively modulate the levels of 1β (1L-1β) in diseased periodontal tissues. Infect Immun. 2008; 76: 3725-34.

17. Scarel-Caminaga RM, Trevilatto PC, Souza AP, Brito RB Jr, Line SR. Investigation of IL4 gene polymorphism in individuals with different levels of chronic periodontitis in a Brazilian population. J Clin Periodontol. 2003; 30: 341-5.

18. Rosenwasser LJ, Klemm DJ, Dresback JK, Inamura H, Mascali JJ, Klinnert M, et al. Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy. 1995; 25 (Suppl 2): 74-8; discussion 95-6.

19. Lotz M, Jirik F, Kabouridis P, Tsoukas C, Hirano T, Kishimoto T, et al. B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes. J Exp Med. 1988; 167: 1253-8.

20. Terry CF, Loukaci V, Green FR. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem. 2000; 275: 18138-44.

21. Revel M. Host defense against infections and inflammations: role of the multifunctional IL-6/IFN-beta 2 cytokine. Experientia. 1989; 45: 549-57.

22. Ishimi Y, Miyaura C, Jin CH, Akatsu T, Abe E, Nakamura Y, et al. IL-6 is produced by osteoblasts and induces bone resorption. J Immunol. 1990; 145: 3297-303.

23. Hughes FJ, Howells GL. Interleukin-6 inhibits bone formation in vitro. Bone Miner. 1993; 21: 21-8.

24. Moreira PR, Lima PM, Sathler KO, Imanishi SA, Costa JE, Gomes RS, et al. Interleukin-6 expression and gene polymorphism are associated with severity of periodontal disease in a sample of Brazilian individuals. Clin Exp Immunol. 2007; 148: 119-26.

25. Trevilatto PC, Scarel-Caminaga RM, de Brito RB Jr, de Souza AP, Line SR. Polymorphism at position -174 of IL-6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brazilian population. J Clin Periodontol. 2003; 30: 438-42.

26. Kim YJ, Viana AC, Curtis KM, Orrico SR, Cirelli JA, Scarel-Caminaga RM. Lack of association of a functional polymorphism in the interleukin 8 gene with susceptibility to periodontitis. DNA Cell Biol. 2009; 28: 185-90.

27. Hajeer AH, Lazarus M, Turner D, Mageed RA, Vencovsky J, Sinnott P, et al. IL-10 gene promoter polymorphisms in rheumatoid arthritis. Scand J Rheumatol. 1998; 27: 142-5.

28. Claudino M, Trombone APF, Cardoso CR Jr SBF Jr WM, Assis GF, et al. The broad effects of the functional 1L-10 promoter -592 polymorphism: modulation of 1L-10, TIMP-3 and OPG expression and their association with periodontal disease outcome. J Leukoc Biol. 2008; 84: 1565-73.

29. Scarel-Caminaga RM, Trevilatto PC, Souza AP, Brito RB, Camargo LE, Line SR. Interleukin 10 gene promoter polymorphisms are associated with chronic periodontitis. J Clin Periodontol. 2004; 31: 443-8.

30. Horewicz VV, Furuse C, Araújo VC, Cury PR. Susceptibilidade genética à periodontite crônica. Revista de Periodontia. 2006; 16: 15.

31. Freitas NM, Imbronito AV, Neves AC, Nunes FD, Pustiglioni FE, Lotufo RF. Analysis of IL-1A (-889) and TNFA (-308) gene polymorphism in Brazilian patients with generalized aggressive periodontitis. Eur Cytokine Netw. 2007; 18: 142-7.

32. Menezes NG, Colombo AP. Lack of association between the TNF-alpha -308 (G/A) genetic polymorphism and periodontal disease in Brazilians. Braz Oral Res. 2008; 22: 322-7.

33. de Souza AP, Trevilatto PC, Scarel-Caminaga RM, Brito RB, Line SR. MMP-1 promoter polymorphism: association with chronic periodontitis severity in a Brazilian population. J Clin Periodontol. 2003; 30: 154-8.

34. de Souza RC, Colombo AP. Distribution of FcgammaRIIa and FcgammaRIIIb genotypes in patients with generalized aggressive periodontitis. J Periodontol. 2006; 77: 1120-8.

35. Fredriksson MI, Gustafsson AK, Bergstrom KG, Asman BE. Constitutionally hyperreactive neutrophils in periodontitis. J Periodontol. 2003; 74: 219-24.

36. Hennig BJ, Parkhill JM, Chapple IL, Heasman PA, Taylor JJ. Association of a vitamin D receptor gene polymorphism with localized early-onset periodontal diseases. J Periodontol. 1999; 70: 1032-8.

37. de Brito Júnior RB, Scarel-Caminaga RM, Trevilatto PC, de Souza AP, Barros SP. Polymorphisms in the vitamin D receptor gene are associated with periodontal disease. J Periodontol. 2004; 75: 1090-5.

38. Costa JE, Gomes CC, Cota LO, Pataro AL, Silva JF, Gomez RS, et al. Polymorphism in the promoter region of the gene for 5-HTT in individuals with aggressive periodontitis. J Oral Sci. 2008; 50: 193-8.

39. Shapira L, Wilensky A, Kinane DF. Effect of genetic variability on the inflammatory response to periodontal infection. J Clin Periodontol. 2005; 32 (Suppl 6): 72-86.

40. Johnson GK, Guthmiller JM. The impact of cigarette smoking on periodontal disease and treatment. Periodontol 2000. 2007; 44: 178‑94.

41. Lindhe J. Tratado de periodontia clínica e implantologia oral. 4a ed. Rio de Janeiro: Guanabara Koogan; 2003.

42. Greenstein G, Hart TC. A critical assessment of interleukin-1 (IL-1) genotyping when used in a genetic susceptibility test for severe chronic periodontitis. J Periodontol. 2002; 73: 231-47.

43. Nevins M, Nevins ML. Genetic susceptibility to periodontal disease. Dent Today. 1998; 17: 94-9.

 

588018cb7f8c9d0a098b4e13 rou Articles
Links & Downloads
1807-2577 (Electronic)
Rev. odontol. UNESP ©2024 All rights reserved.

Rev. odontol. UNESP

Share this page
Page Sections