Adenocarcinoma polimorfo de baixo grau de malignidade do tipo papilífero. estudo morfológico e imuno-histoquímico
Polymorphous low-grade adenocarcinoma of the papillary type. A morphological and immunohistochemical study
Carvalho, Y.R.; Nogueira, T.O.; Souza, S.O.M.; Araújo, V.C.
Rev. odontol. UNESP, vol.19, nÚnico, p.165-171, 1990
Resumo
No presente trabalho foram estudados dois casos de adenocarcinoma polimorfo de baixo grau de malignidade do tipo papilífero, de glândulas salivares menores, através de microscopia de luz e imuno-histoquímica. Um dos casos exibiu predominância do padrão papilífero, enquanto o outro apresentou os seguintes padrões histológicos: papilífero, sólido, pseudocístico e tubular. Utilizando o método da peroxidase-antiperoxidase (PAP), o filamento intermediário vimentina, queratina e a proteína S100 foram observados nas células tumorais. A análise imunohistoqulmica revelou dois tipos de células neoplásicas: mioepitelial e luminal.
Palavras-chave
Neoplasias de glândulas salivares, adenocarcinoma, imuno-histoquímica
Abstract
Two cases or polymorphous low-grade adenocarcinoma or the papillary type, from minor salivary glands were studied by light microscopy and immunohistochemistry. One case exhibited a predominance or the papillary pattem, whereas the other presented the rollowing patterns or histological appearance: papillary, solid, pseudocystic mui tubular. Utilizing the peroxidase-antiperoxidase (PAP) method, the intermediate filament vimentin, keratin and 5100 protein were observed in tumor cells. The immunohistochemical analysis revealed two types of neoplastic cells: myoepithelial and luminal.
Keywords
Salivary gland neoplasms, adenocarcinoma, immunohistochemistry
References
1. ALLEN, Jr., M. S.; FITZ-HUGH, G. S. & MARSH Jr., W. L. - Low-grade papillary adenocarcinoma of the palate. Cancer,33: 153-8, 1974.
2. ARAÚJO, V. C.; SOUZA, S. O. M.; LOPES, E. A.; ARAÚJO, N. S. & SESSO, A. Mucus- producing adenopapillary carcinoma of minor salivary gland origin with signet' ring cells and intracytoplasmic lumina. A light and clectron microscopic study. Arch. Otorhinolaryngol.,245: 145-50, 1988.
3. BLANCK, C.; ENEROTH, C. M. & JAKOBSSON, P. A. - Mucus-producing adenopapillary (non-epidermoid) carcinoma 01' the parotid gland. Cancer 28: 676-85, 1971.
4. CHAUDHRY, A. P.; CUTLER, L. S.; LEIFER, c.; SATCHIDANAND, S.; LABAY, G. & YAMANE, G. - Histogenesis of acinic cell carcinoma of the major and minor salivary glands. An ultrastructural study. J. Palhol., 148: 307-20,1986.
5. CROKER, T. P.; KREUTNER Ir.; A.; OTHERSEN, H. B. & GARVIN, A. J. - Papillary adenocarcinoma of minor salivary gland origin in a child. Arch. Otolaryngol., 109: 827-31,1983.
6. EVANS. H. L. & BATSAKIS, I. G. - Polymorphous low-grade adenocarcinoma of minor salivary glands. A study of 14 cases of a distinctive neoplas. Cancer, 53: 935-42, 1984.
7. FRIERSON, H. F.; MILLS, S. E. & GARLAND, T. A. - Tenninal duct carcinoma of minor salivary glands. A non-papillary subtype of polymorphous low-grade adenocarcinoma. Am. J. Clin. Patho!., 84: 8-14, 1985.
8. GNEPP, D. R.; I. C. & WARREN, C. - Polymorphous low-grade adenocarcinoma of minor salivary glande An immunohistochemical and clinicopathologic study. Am. J. Surg.Pathol., 12:461-8,1988.
9. HARA, K.; ITO, M.; TAKEUCHI, I.; TIJlMA, S.; ENDO, T. & HIDAKA, H. - Distribution of S100b protein normal salivary glands and salivary gland tumors. Virchows Arch. (A), 401: 237-49, 1983.
10. MELROSE, R. J.; ABRAMS, A. M.; & HOWELL, F. V. - Mucoepidermoid tumors of the intraoral minor salivary glands: a clinicopathologic study of 54 cases. J. oral Pathol., 2: 314-25, 1973.
11. MILLS, S. E.; GARLAND, T. A; & ALLEN Ir., M. S. - Low-grade papillary adenocarcinoma of palatal salivary gland origino Am. J. Surge Pathol., 8: 367-74, 1984.
12. NAKAZATO, Y.; ISHIDA, Y.; TAKAHASHI, K. & SUZUKI, K. - Immunohistochemical distribution of SI00 protein and glial fibrillary acidic protein in nonÍlal and neoplastic salivary glands. Virchows Arch. (A), 405: 299-310, 1985.
13. RUSSEL Jr., E. A. & NELSON, J. F. - Adenocarcinoma of the palate: diagnosis and management. Oral Surg., 45: 528-31, 1987.
14. SATO, M.; HAYASHI, Y.; YOSHIDA, H.; YANAGAWA, T.; YURA, Y. & NITTA, T. - Search for specific markers of neoplastic epithelial duct and myoepithelial cell tines established from human salivary gland and characterization of their growth ip vitro. Cancer, 54: 2959-67, 1984.
15. SEIFERT, G. & SCHULZ, J. P. - Das adenokarzinom der speicheldrüsen. Pathohistologie und subklassifikation Von 77 fãllen. HNO, 33: 433-42, 1985.
16. SLOOTWEG, P. J. & MÜLLER, H. - Low-grade adenocarcinomà of the oral cavity. J. Cranio-Max:-Fac. Surg., 15: 359-364, 1987.
17. SPIRO, R. H.; HUVOS, A. G.; BERK, R. & STRONG, E. W. - Mucoepidermoid carcinoma of salivary gland origino A clinicopathologic study of 367 cases. Am. J. Surg., 136: 461-8, 1978.
18. SPIRO, R. H.; KOSS, L. G.; HAJDU, S. I. & STRONG, E. W. - Tumors ofminor salivary origino A clinicopathologic study of 492 cases. Cancer, 31: 117-29, 1973.
19. STERNBERGER, L. A.; HARDY, P. H.; CUCULIS, J. J. & MEYER, H. G. - Preparation and properties of soluble antigen-antibody complex (horseradish peroxidase antihorseradish peroxidase) and its use in identification of spirochetes. J. Histochem. Cytochem., 18: 315-33, 1970.
20. WHITTAKER, J. S. & TURNER, E. P. - Papillary tumours of the minor salivary glands. J. Clin. Pathol., 29: 795-805, 1976.
Facebook
Google+
Twitter
LinkedIn
Mendeley
StumbleUpon
CiteULike
Reddit
Email