Revista de Odontologia da UNESP
https://revodontolunesp.com.br/journal/rou/article/588017b07f8c9d0a098b4859
Revista de Odontologia da UNESP
Original Article

Descrição da metodologia utilizada no estudo da carcinogênese induzida pelo DMBA em língua de hamster

Description of a methodology used in the study of DMBA-induced hamster tongue carcinogenesis

Bolanho, A.; Carmo, E.D.; Sousa, F.A.C.G.; Carvalho, Y.R.; Rosa, L.E.B.

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Resumo

O câncer representa uma das principais causas de morte no Brasil e no mundo, o que o torna alvo de inúmeras pesquisas. Assim, atualmente se busca cada vez mais entender as etapas que compõem o processo de carcinogênese. Sob este aspecto, os trabalhos que tentam reproduzir experimentalmente tais etapas fornecem uma fonte inesgotável de conhecimento. Por isso, o objetivo deste trabalho foi descrever a metodologia utilizada para a implantação de um modelo experimental para o estudo da carcinogênese química induzida na língua de hamsters.

Palavras-chave

Câncer bucal, carcinogênese experimental, 9,10-dimetil-1,2-benzantraceno, hamsters.

Abstract

Cancer represents one of the main causes of death in Brazil and in the world, being the target of several researches. Nowadays, there is a search for understanding the steps whose compose the carcinogenesis process. In this aspect, the studies which try to experimentally reproduce such steps are source of everlasting knowledge with. Thus, the purpose of this study was to describe the methodology employed during the implementation of an experimental model to study chemically-induced tongue carcinogenesis.

Keywords

Mouth neoplasms, experimental carcinogenesis, 9,10-dimethyl-1,2‑benzanthracene, hamsters.

References



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