Revista de Odontologia da UNESP
https://revodontolunesp.com.br/article/doi/10.1590/1807-2577.03722
Revista de Odontologia da UNESP
Original Article

Fatores de risco associados à osteorradionecrose dos maxilares em pacientes com câncer de cavidade oral e orofaringe

Risk factors associated with osteoradionecrosis of the mandible in patients with cancer pf oral cavity and oropharynx

Camila Ferreira MARCONDES; João Victor Soares RODRIGUES; Elizangela Cruvinel ZUZA; Helio Massaiochi TANIMOTO; Eliane Marçon BARROSO

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Resumo

Resumo: Introdução: A osteorradionecrose dos maxilares (ORN) é uma conhecida complicação relacionada à radioterapia, tendo grande impacto e podendo acometer indivíduos submetidos a radioterapia para tratamento de câncer da cavidade oral associado a uma condição dental desfavorável.

Objetivo: Este estudo teve como objetivo avaliar e determinar a influência de fatores sociodemográficos e clínicos associados à ORN em indivíduos com câncer de cavidade oral e orofaringe submetidos a radioterapia atendidos no Departamento de Odontologia do Hospital de Câncer de Barretos entre os anos de 2007-2017.

Material e método: Trata-se de um estudo caso-controle com coleta de dados retrospectivos em prontuários.

Resultado: Os dados coletados correspodem a 83 prontuários selecionados, sendo 31 correspondentes ao grupo caso e 52 correspondentes ao grupo controle. Evidenciou-se uma média (desvio padrão) de idade para indivíduos dos grupos caso e controle de 65,44 (7,49) e 65,02 (10,08), respectivamente. Em ambos os grupos houve predominância do sexo masculino. A média (desvio padrão) do intervalo entre a última sessão de radioterapia e a data do diagnóstico de ORN foi de 26,42 (27,51) meses. A presença de doença periodontal no diagnóstico [OR=6,253; (IC95%1,25-31,12; p=0,025)] e exodontia [OR = 6,148; (IC95%) 1,14-26,23; p= 0,014) após radioterapia resultou em uma maior chance de desenvolver a ORN.

Conclusão: A partir dos resultados obtidos, conclui-se que os principais fatores de risco para desenvolvimento da ORN em indivíduos com câncer de cavidade oral e orofaringe são exodontia após radioterapia e presença de periodontite no diagnóstico.

Palavras-chave

Osteorradionecrose, neoplasia de cabeça e pescoço, radioterapia

Abstract

Abstract: Introduction: Osteoradionecrosis of the mandible (ORNM) is a well-known complication related to radiotherapy that can affect patients undergoing radiotherapy to treat oral cavity cancer associated with an unfavorable dental condition.

Objective: This study aimed to assess and determine the influence of sociodemographic and clinical factors associated with osteoradionecrosis on patients with cancer of oral cavity and oropharynx undergoing radiotherapy treated at the Department of Dentistry of the Barretos Cancer Hospital between 2007- 2017.

Materials and method: This is a case-control study with retrospective data collection from medical records.

Result: The data were collected from 83 medical records, 31 corresponding to the case group and 52 corresponding to the control group. The patients in the case and control groups were aged in average (standard deviation) 65.44 (7.49) and 65.02 (10.08) years, respectively. Both groups had a predominance of male individuals. The mean (standard deviation) interval between the last radiotherapy session and the date of osteoradionecrosis diagnosis was 26.42 (27.51) months. The presence of periodontal disease at diagnosis [OR = 6,253; (95% CI 1.25-31.12; p = 0.025)] and tooth extraction [OR = 6.148; (95% CI) 1.14-26.23; p = 0.014] after radiotherapy resulted in greater chances of developing osteoradionecrosis.

Conclusion: Based on our results, extraction after radiotherapy and the presence of periodontitis in the diagnosis of patients with cancer of oral cavity and oropharynx are the main risk factors for the development of osteoradionecrosis.
 

Keywords

Osteoradionecrosis, head and neck neoplasia, radiotherapy

References

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Submitted date:
10/26/2022

Accepted date:
11/16/2022

639a04dfa9539519ca30f4b3 rou Articles
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