FLUORIDE INCORPORATION INTO DEVELOPING MOLAR TEETH OF RATS
Incorporação de flúor em molares em desenvolvimento em ratos.
Rosa Anita Rocca, Sérgio Miguel Zucas, Orlando Ayrton de Toledo
Abstract
A quantitative analysis of fluoride was made in molar teeth of rats aged 10,20,30 and 60 days. The animals were daily injected subcutaneously, since birth to sacrifice, with 0,15 mg/NaF (0.067 mg/F) or 0.30 mg/NaF (0.134 mg/F). The comparative study of the data with those observed in molar teeth of rats without any treatment evidenced that: the adminiseered fluoride dosis did not affeet the molar teeth development or even the somatie growth of the animais as showcd by weighe evaluation; the molar teeth of rats exhibit gradual reduction of the eapacity for fluoride fixation durind mineralization process; and the percentual fixation of injected fluoride presented similar results for both tested dosis.
Keywords
Resumo
Foi efetuada a análise quantitativa do flúor presente nos molares de ratos com 10, 20, 30 e 60 dias de idade, que receberam, desde o nascimento, doses diárias de 0,15 mg/NaF ou 0,30 mg/NaF, injetadas subcutaneamente. O estudo comparativo dos dados obtidos, com aqueles observados nos molares de ratos da mesma idade, não tratados, evidenciou que: 1) as doses de flúor administradas não afetaram, de maneira consistente, o crescimento somático dos animais, nem dos molares; 2) os molares do rato perdem gradualmente sua capacidade para acumular flúor durante o processo de mineralização e 3) o percentual de flúor fixado mostrou comportamento similar para ambas as doses testadas.
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References
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