Revista de Odontologia da UNESP
Revista de Odontologia da UNESP
Original Article

Tissue engineering application in sinus lifting procedures. A systematic literature review

Aplicação de engenharia tecidual na elevação de seio maxilar: uma revisão sistemática da literatura

Oliveira, Guilherme José Pimentel Lopes de; Nogueira, Andressa Vilas Boas; Spin-Neto, Rubens; Faeda, Rafael Silveira; Marcantonio, Rosemary Adriana Chiérici; Marcantonio Jr, Elcio

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The purpose of this literature review is to present the state-of-the-art on the application of tissue engineering techniques in sinus lifts procedures, reporting the influence of these techniques in increasing bone height and volume in the maxillary sinus, and the osseointegration of the implants installed in the grafted areas. PubMed and Scopus databases were searched using the keywords "scaffold" OR "engineered tissue" AND "sinus augmention" OR "sinus floor elevation." In the initial search 463 articles were selected, of which 19 were selected abstracts reading, with nine papers selected by the end, for evaluation of the application of tissue engineering techniques in sinus lift procedures. Despite the positive results of tissue engineering procedures in sinus floor elevation reported in the selected articles, further studies are still needed, for a better standardization of experimental models and materials used, leading to definitive conclusions about the effects of the application of tissue engineering procedures on bone formation in maxillary sinus lifting procedures.


Biomaterials, growth factors, sinus lift, tissue engineering.


O objetivo desta revisão de literatura é apresentar a aplicação da engenharia tecidual em cirurgias de elevação de assoalho do seio maxilar, relatando a influência dessas técnicas no aumento da altura e do volume ósseos no seio maxilar, e na osseointegração dos implantes instalados nas áreas enxertadas. A revisão foi realizada nas bases de dados PubMed e Scopus, utilizando-se as palavras-chave “scaffold” OR “tissue engineered” AND “sinus augmention” OR “sinus floor elevation”. Na busca inicial, 463 artigos foram selecionados, dos quais 19 artigos para leituras dos abstracts, chegando ao final a nove artigos, que foram selecionados para avaliação da aplicação da engenharia tecidual em cirurgias de elevação do seio maxilar. Apesar dos resultados positivos da engenharia tecidual em procedimentos de elevação do seio maxilar relatados nos artigos selecionados, existe a necessidade de mais estudos, com melhor padronização de modelos experimentais e dos materiais utilizados, para que se chegue a conclusões convictas acerca do efeito da aplicação da engenharia tecidual na formação óssea em procedimentos de elevação de seio maxilar.


Biomateriais, engenharia tecidual, fatores de crescimento, levantamento de seio maxilar.


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