Revista de Odontologia da UNESP
https://revodontolunesp.com.br/article/588018f17f8c9d0a098b4ed0
Revista de Odontologia da UNESP
Review Article

Effect of bisphosphonate on periodontal disease – narrative review of literature

Efeito dos bisfosfonatos na doença periodontal: revisão narrativa da literatura

Goes, Paula; Lima, Vilma de

Rev. odontol. UNESP, vol.40, n5, p.255-263, 2011
PDF
Downloads: 4
Views: 1407

Abstract

This work evaluated the effect of Bisphosphonates (BPs) on periodontitis through a narrative review of literature. For this, it was searched articles in several computadorized database such as PubMed, Lilacs, Scielo, Medline and Central Register of Controlled Trials (COCHRANE/CCTR), using the keywords: Bisphosphonates and Periodontal disease. It was searched articles related to pre-clinical and clinical assays involving the systemic uses of BP on periodontitis, published in English or Portuguese, in the last 10 years. Initially, 144 references were found. From analysis of titles and abstracts, and considering inclusion and exclusion criterias, 17 full papers were included, being 11 studies in vivo preclinical and 6 clinical trials. Of these, 13 studies concluded that treatment with BFs prevented, significantly, the alveolar bone loss by changing the number and morphology of osteoclasts, 10 studies showed modulating inflammation, reducing recruitment of neutrophils, myeloperoxidase activity, inflammatory mediators, matrix metalloproteinases, and gingival bleeding index. Two studies also showed reduction on serum levels of N-terminal cross-linking telopeptide of type I collagen and one showed reduction on Bone-specific alkaline phosphatase, In summary, the treatment with BFs prevented alveolar bone resorption, modulated inflammation, and reduced serum levels of biochemical markers of bone metabolism, with improvement of clinical periodontal parameters, being therefore, an important pharmacological approach to be suggested as adjunct to basic periodontal therapy.

Keywords

Bisphosphonates, periodontitis, inflammation

Resumo

Este trabalho avaliou o efeito dos Bisfosfonatos (BFs) na periodontite por meio de uma revisão narrativa da literatura. Para tanto, buscaram-se artigos em diversas bases de dados computadorizadas, tais como PubMed, Lilacs, Scielo, Medline e o Centro de Registro de Ensaios Clínicos da Biblioteca Cochrane (COCHRANE/CCTR), utilizando-se as palavras- chave: “Bisphosphonates” e “Periodontal Disease”. Foram buscados artigos relacionados a ensaios pré-clínicos e clínicos envolvendo os usos sistêmicos de BFs na periodontite, publicados em língua inglesa ou portuguesa nos últimos dez anos. Inicialmente, foram encontradas 144 referências. A partir de análises de títulos e resumos, seguindo critérios de inclusão e exclusão, 17 artigos completos foram incluídos, sendo 11 estudos pré-clínicos in vivo e seis ensaios clínicos. Desses, 13 concluíram que o tratamento com BFs preveniu, de forma significante, a perda óssea alveolar por meio de alteração de número e morfologia de osteoclastos, dez estudos mostraram modulação da inflamação, redução do recrutamento de neutrófilos, da atividade de mieloperoxidase, de mediadores inflamatórios e metaloproteinases de matriz, bem como de índices de sangramento gengival. Dois estudos mostraram redução dos níveis séricos de Telopeptídeo N-terminal de colágeno tipo I, enquanto outro mostrou redução de Fosfatase Alcalina Óssea, marcadores do metabolismo ósseo. Em suma, o tratamento com BFs preveniu a reabsorção óssea alveolar, modulou a inflamação e reduziu o nível sérico de marcadores bioquímicos do metabolismo ósseo, com melhora dos parâmetros clínicos periodontais; esse tratamento é, portanto, uma importante abordagem farmacológica a ser sugerida como adjuvante à terapia periodontal básica.

Palavras-chave

Bisfosfonato, periodontite, inflamação

References

 


1. Darveau RP. Periodontitis: a polymicrobial disruption of host homeostasis. Nat Rev Microbiol. 2010; 8:481-90. PMid:20514045. http:// dx.doi.org/10.1038/nrmicro2337

2. Salvi GE, Lang NP. Host response modulation in the management of periodontal diseases. J Clin Periodontol. 2005; 32(Suppl 6): 108-29. PMid:16128833. http://dx.doi.org/10.1111/j.1600-051X.2005.00785.x

3. Russell RGG, Watts NB, Ebetino FH, Rogers MJ. Mechanisms of action of Bisphosphonates: similarities and differences and their potencial influence on clinical efficacy. Osteoporos Int. 2008; 19: 733-59. PMid:18214569. http://dx.doi.org/10.1007/s00198-007-0540-8

4. Watts NB, Diab DL. Long-term use of bisphosphonates in osteoporosis. J Clin Endocrinol Metab. 2010;95:1555-65. http://dx.doi. org/10.1210/jc.2009-1947

5. Badran Z, Kraehenmann MA, Guicheux J, Soueidan A. Bisphosphonates in periodontal treatment: a review. Oral Health Prev Dent. 2009;7(1):3-12. PMid:19408809.

6. Teronen O, Heikkila P, Konttinen YT, Laitinen M, Salo T, Hanemaaijer R, et al. MMP inhibition and downregulation by bisphosphonates. Ann N Y Acad Sci. 1999;878:453-65. PMid:10415748. http://dx.doi.org/10.1111/j.1749-6632.1999.tb07702.x

7. Benford HL, Mcgowan NW, Helfrich MH, Nuttall ME, Rogers MJ. Visualization of bisphosphonate-induced caspase-3 activity in apoptotic osteoclasts in vitro. Bone. 2001;28:465-73. http://dx.doi.org/10.1016/S8756-3282(01)00412-4

8. Alencar VB; Bezerra,MM, Lima V, Abreu AL, Brito GA, Rocha FA, et al. Disodium chlodronate prevents bone resorption in experimental periodontitis in rats. J Periodontol. 2002; 73: 251-6. PMid:11924589. http://dx.doi.org/10.1902/jop.2002.73.3.251

9. Llavaneras A, Ramamurthy NS, Heikkilä P, Teronen O, Salo T, Rifkin BR, et al. A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats. J Periodontol. 2001;72:1069-77. PMid:11525440. http://dx.doi.org/10.1902/jop.2001.72.8.1069

10. Tani-Ishii N, Minamida G, Saitoh D, Chieda K, Omuro H, Sugaya A, et al. Inhibitory effects of incadronate on the progression of rat experimental periodontitis by Porphyromonas gingivalis infection. J Periodontol. 2003; 74:603-9. PMid:12816291. http://dx.doi. org/10.1902/jop.2003.74.5.603

11. Buduneli E, Vardar S, Buduneli N, Berdeli AH, Türkoğlu O, Başkesen A, et al. Effects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in rats. J Periodontol. 2004; 75:1516-23. PMid:15633329. http://dx.doi. org/10.1902/jop.2004.75.11.1516

12. Duarte PM, de Assis DR, Casati MZ, Sallum AW, Sallum EA, Nociti FH Jr. Alendronate may protect against increased periodontitis-related bone loss in estrogen-deficient rats. J Periodontol. 2004;75:1196-202. PMid:15515333. http://dx.doi.org/10.1902/jop.2004.75.9.1196

13. Buduneli E, Buduneli N, Vardar-Sengül S, Kardeşler L, Atilla G, Lappin D, et al.. Systemic low-dose doxycycline and alendronate administration and serum interleukin-1beta, osteocalcin, and C-reactive protein levels in rats. J Periodontol. 2005;76:1927-33. PMid:16274312. http://dx.doi.org/10.1902/jop.2005.76.11.1927

14. Menezes AM, Rocha FA, Chaves HV, Carvalho CB, Ribeiro RA, Brito GA. Effect of sodium alendronate on alveolar bone resorption in experimental periodontitis in rats. J Periodontol. 2005;76:1901-9. PMid:16274309. http://dx.doi.org/10.1902/jop.2005.76.11.1901

15. Anbinder AL, Prado Fde A, Prado M de A, Balducci I, Rocha RF. The influence of ovariectomy, simvastatin and sodium alendronate on alveolar bone in rats. Braz Oral Res. 2007;21:247-52. PMid:17710291.

16. Buduneli E, Vardar-Sengül S, Buduneli N, Atilla G, Wahlgren J, Sorsa T. Matrix metalloproteinases, tissue inhibitor of matrix metalloproteinase-1, and laminin-5 gamma2 chain immunolocalization in gingival tissue of endotoxin-induced periodontitis in rats: effects of low-dose doxycycline and alendronate. J Periodontol. 2007;78:127-34. PMid:17199549. http://dx.doi.org/10.1902/jop.2007.050451

17. Spolidorio LC, Marcantonio E Jr, Spolidorio DM, Nassar CA, Nassar PO, Marcantonio RA, Rossa C Jr. J. Alendronate therapy in cyclosporine-induced alveolar bone loss in rats. J Periodontal Res. 2007;42:466-73. PMid:17760825. http://dx.doi.org/10.1111/j.1600- 0765.2007.00970.x

18. Cetinkaya BO, Keles GC, Ayas B, Gurgor P. Effects of risedronate on alveolar bone loss and angiogenesis: a stereologic study in rats. J Periodontol. 2008;79:1950-61. PMid:18834251. http://dx.doi.org/10.1902/jop.2008.080041

19. Rocha M, Nava LE, Vázquez De La Torre C, Sánchez-Márin F, Garay-Sevilla ME, Malacara JM. Clinical and radiological improvement of periodontal disease in patients with type 2 diabetes mellitus treated with alendronate: a randomized, placebo-controlled trial. J Periodontol. 2001;72:204-9. PMid:11288794. http://dx.doi.org/10.1902/jop.2001.72.2.204

20. El-Shinnawi UM, El-Tantawy SI. The effect of alendronate sodium on alveolar bone loss in periodontitis (clinical trial). J Int Acad Periodontol. 2003;5(1):5-10. PMid:12666950.

21. Rocha ML, Malacara JM, Sánchez-Marin FJ, Vazquez De La Torre CJ, Fajardo ME. Effect of alendronate on periodontal disease in postmenopausal women: a randomized placebo-controlled trial. J Periodontol. 2004;75:1579-85. PMid:15732857. http://dx.doi. org/10.1902/jop.2004.75.12.1579

22. Lane N, Armitage GC, Loomer P, Hsieh S, Majumdar S, Wang HY, et al. Bisphosphonate therapy improves the outcome of conventional periodontal treatment: results of a 12-month, randomized, placebo-controlled study. J Periodontol. 2005;76:1113-22. PMid:16018754. http://dx.doi.org/10.1902/jop.2005.76.7.1113

23. Jeffcoat MK, Cizza G, Shih WJ, Genco R, Lombardi A. Efficacy of bisphosphonates for the control of alveolar bone loss in periodontitis. J Int Acad Periodontol. 2007;9(3):70-6. PMid:17715838.

24. Graziani F, Cei S, Guerrero A, La Ferla F, Vano M, Tonetti M, et al. Lack of short-term adjunctive effect of systemic neridronate in non-surgical periodontal therapy of advanced generalized chronic periodontitis: an open label-randomized clinical trial. J Clin Periodontol. 2009;36:419-27. PMid:19419443. http://dx.doi.org/10.1111/j.1600-051X.2009.01388.x

25. Nancollas GH, Tang R, Phipps RJ, Henneman Z, Gulde S, Wu W, et al. Novel insights into actions of bisphosphonates on bone: differences in interactions with hydroxyapatite. Bone. 2006;38:617-27. PMid:16046206. http://dx.doi.org/10.1016/j.bone.2005.05.003

26. Ryan P, Saleh I, Stassen LF. Osteonecrosis of the jaw: a rare and devastating side effect of bisphosphonates. Postgrad Med J. 2009;85(1010):674‑7. Review. PMid:20075406. http://dx.doi.org/10.1136/pgmj.2008.076349

27. Russell RG. Bisphosphonates: the first 40 years. Bone. 2011;49(1):2-19. PMid:21555003. http://dx.doi.org/10.1016/j.bone.2011.04.022

28. Tenenbaum HC, Shelemay A, Girard B, Zohar R, Fritz PC. Bisphosphonates and periodontics: potential applications for regulation of bone mass in the periodontium and other therapeutic/diagnostic uses. J Periodontol. 2002;73:813-22. PMid:12146541. http://dx.doi. org/10.1902/jop.2002.73.7.813

29. Takahashi N, Ejiri S, Yanagisawa S, Ozawa H. Regulation of osteoclast polarization. Odontology 2007;95(1):1-9. PMid:17660975. http:// dx.doi.org/10.1007/s10266-007-0071-y

30. Pietschmann P, Stohlawetz P, Brosch S, Steiner G, Smolen JS, Peterlik M. The effect of alendronate on cytokine production, adhesion molecule expression, and transendothelial migration of human peripheral blood mononuclear cells. Calcif Tissue Int. 1998;63:325-30. PMid:9744992. http://dx.doi.org/10.1007/s002239900535

31. Sethi S, Dikshit M. Modulation of polymorphonuclear leukocytes function by nitric oxide. Thromb. Res. 2000;100:223-47. http://dx.doi. org/10.1016/S0049-3848(00)00320-0

32. Salvolini E, Orciani M, Vignini A, Di Primio R, Mazzanti L.The effects of disodium pamidronate on human polymorphonuclear leukocytes and platelets: an in vitro study.Cell Mol Biol Lett. 2009;14:457-65. http://dx.doi.org/10.2478/s11658-009-0012-6

33. Hikiji H, Takato T, Shimizu T, Ishii S. The roles of prostanoids, leukotrienes, and platelet-activating factor in bone metabolism and disease. Prog Lipid Res. 2008;47:107-26. PMid:18187046. http://dx.doi.org/10.1016/j.plipres.2007.12.003

34. Cochran DL. Inflammation and bone loss in periodontal disease. J Periodontol. 2008;79(8 Suppl):1569-76. PMid:18673012. http://dx.doi. org/10.1902/jop.2008.080233

35. Blackwell KA, Raisz LG, Pilbeam CC. Prostaglandins in bone: bad cop, good cop? Trends Endocrinol Metab. 2010;21:294-301. http:// dx.doi.org/10.1016/j.tem.2009.12.004

36. Garcia C, Boyce BF, Gilles J, Dallas M, Qiao M, Mundy GR, et al. Leukotriene B4 stimulates osteoclastic bone resorption both in vitro and in vivo. J Bone Miner Res. 1996;11:1619–27. PMid:8915769. http://dx.doi.org/10.1002/jbmr.5650111105

37. Hikiji H, Ishii S, Yokomizo T, Takato T, Shimizu T. A distinctive role of the leukotriene B4 receptor BLT1 in osteoclastic activity during bone loss. Proc Natl Acad Sci USA. 2009;106(50):21294-9. PMid:19965376. PMCid:2795503. http://dx.doi.org/10.1073/pnas.0905209106

38. Weicht B, Maitz P, Kandler B, Fischer MB, Watzek G, Gruber R. Activated platelets positively regulate RANKL-mediated osteoclast differentiation. J Cell Biochem. 2007;102:1300-7. PMid:17957725. http://dx.doi.org/10.1002/jcb.21360

39. Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, et al. Matrix metalloproteinases: a review. Crit Rev Oral Biol Med.1993;4:197-250. PMid:8435466.

40. Vaisman DN, McCarthy AD and Cortizo AM. Bone-specific alkaline phosphatase activity is inhibited by bisphosphonates: role of divalent cations. Biol Trace Elem Res 2005;104:131-40. http://dx.doi.org/10.1385/BTER:104:2:131

41. Yamaguchi K, Motegi K, Iwakura Y, Endo Y. Involvement of interleukin-1 in the inflammatory actions of aminobisphosphonates in mice. Br J Pharmacol. 2000;130:1646-54. PMid:10928970. PMCid:1572219. http://dx.doi.org/10.1038/sj.bjp.0703460

42. Endo Y, Shibazaki M, Nakamura M, Kosugi H. Inhibition of inflammatory actions of aminobisphosphonates by dichloromethylene bisphosphonate, a nonaminobisphosphonate. Br J Pharmacol. 1999;26:903–10. PMid:10193770. PMCid:1571205. http://dx.doi. org/10.1038/sj.bjp.0702367

43. Deng X, Yu ZQ, Funayama H, Shoji N, Sasano T, Iwakura Y, et al. Mutual augmentation of the induction of the histamine-forming enzyme, histidine decarboxylase, between alendronate and immuno-stimulants (IL-1, TNF, and LPS), and its prevention by clodronate. Toxicol Appl Pharmacol. 2006;213:64–73. PMid:16203021. http://dx.doi.org/10.1016/j.taap.2005.09.005

44. Rizzoli R, Reginster JY, Boonen S, Bréart G, Diez-Perez A, Felsenberg D, et al. Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis. Calcif Tissue Int. 2011;89:91-104. PMid:21637997. PMCid:3135835. http:// dx.doi.org/10.1007/s00223-011-9499-8

45. Papapetrou PD. Bisphosphonate-associated adverse events. Hormones (Athens). 2009;8:96-110.

46. Amano A. Bacterial adhesins to host components in periodontitis. Periodontol 2000. 2010;52:12-37. PMid:20017793. http://dx.doi. org/10.1111/j.1600-0757.2009.00307.x

47. Oscarsson J, Karched M, Thay B, Chen C, Asikainen S. Proinflammatory effect in whole blood by free soluble bacterial components released from planktonic and biofilm cells. BMC Microbiol. 2008;8:206. PMid:19038023. PMCid:2612679. http://dx.doi.org/10.1186/1471-2180- 8-206

48. Chesnut CH 3RD, Bell NH, Clark GS, Drinkwater BL, English SC, Johnson CCJR, et al. Hormone replacement therapy in postmenopausal women: urinary N-telopeptide of type I collagen monitors therapeutic effect and predicts response of bone mineral density. Am J Med. 1997;102(1):29-37. http://dx.doi.org/10.1016/S0002-9343(96)00387-7

49. Iwamoto J, Sato Y, Uzawa M, Takeda T, Matsumoto H. Comparison of effects of alendronate and raloxifene on lumbar bone mineral density, bone turnover, and lipid metabolism in elderly women with osteoporosis. Yonsei Med J. 2008; 49(1):119-28. PMid:18306478. PMCid:2615270. http://dx.doi.org/10.3349/ymj.2008.49.1.119

50. Bell NH, Bilezikian JP, Bone HG 3RD, Kaur A, Maragoto A, Santora AC. MK-063 Study Group. Alendronate increases bone mass and reduces bone markers in postmenopausal African-American women. J Clin Endocrinol Metab. 2002;87:2792-7. http://dx.doi.org/10.1210/ jc.87.6.2792

 

588018f17f8c9d0a098b4ed0 rou Articles
Links & Downloads
1807-2577 (Electronic)
Rev. odontol. UNESP ©2024 All rights reserved.

Rev. odontol. UNESP

Share this page
Page Sections