Revista de Odontologia da UNESP
https://revodontolunesp.com.br/article/588018d17f8c9d0a098b4e31
Revista de Odontologia da UNESP
Original Article

Antifungal activity of borax-based formula on Candida spp.

Atividade antifúngica de formulação à base de bórax sobre leveduras do gênero Candida

Santos, Silvana Soléo Ferreira dos; Pereira, Daniel Freitas Alves; Martins, Clélia Aparecida de Paiva; Zöllner, Maria Stella Amorin da Costa; Jorge, Antonio Olavo Cardoso; KOGA-ITO, Cristiane Yumi Koga-Ito

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Abstract

Introduction: The interest in new antifungal agents that may help the control of Candida spp. related lesions has been increasing. Oral reservoirs of opportunistic microorganisms have the potential to cause systemic infections, in particular in immunocompromised patients. Objective: This study evaluated the antifungal effect of a borax-based formula with water of roses and honey on Candida albicans clinical and standard strains and two Candida dubliniensis standard strains. Method: The method adopted was dilution in Müeler-Hinton agar (Difco®). The complete formula and its constituents were evaluated at different concentrations. Result: The complete formula showed inhibitory effect against all the tested isolates at the concentration of 6.75%. The results showed that borax solutions were more efficient when compared to the other constituents of the formula. Borax solutions showed high antifungal activity even in low concentrations. The addition of the honey and water of roses reduced their effectiveness. Conclusion: The results suggest that borax is the responsible for the biological effect of the formula and that it can be used as adjuvant in the control of fungal oral infections.

Keywords

Candida spp., borax, honey, water of roses

Resumo

Introdução: A descoberta de novos agentes que possam ajudar no controle de lesões bucais causadas por leveduras do gênero Candida vem despertando interesse, visto que reservatórios bucais de micro-organismos oportunistas têm potencial para causar infecções sistêmicas, especialmente em pacientes imunocomprometidos. Objetivo: O objetivo do estudo foi avaliar o efeito antifúngico de uma formulação de bórax, água de rosas e mel, in vitro, sobre cepas clínicas e padrão de C. albicans, e amostras padrão de C. dubliniensis. Material e método: O método utilizado foi de diluição em ágar Müeler-Hinton (Difco®). A formulação completa e seus constituintes isolados foram avaliados em diferentes concentrações. Resultado: Observou-se que a associação foi inibitória para todas as cepas testadas na concentração de 6,75%. Os resultados mostraram que soluções de bórax isoladamente apresentaram melhor eficácia se comparadas às soluções com outros constituintes ou até mesmo à formulação, com efeito antifúngico a partir da concentração de 0,0625%. O bórax isolado apresentou maior efetividade antifúngica a baixas concentrações. Quando da adição do mel ou água de rosas, observou-se redução da efetividade. Conclusão: Os resultados sugerem que o bórax é o responsável pelo efeito biológico da fórmula e que esta pode ser aplicada como coadjuvante no controle de infecções fúngicas bucais.

Palavras-chave

Candida spp., bórax, mel, água de rosas

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