Polymorphous low-grade adenocarcinoma: case report and an update about the main aspects of its diagnosis
Adenocarcinoma polimorfo de baixo grau: relato de um caso adicional e uma atualização aos principais aspectos sobre seu diagnóstico
Morais, Maria de Lourdes Silva de Arruda; Sarmento, Dmitry José de Santana; Silveira, Éricka Janine Dantas da; Oliveira, Isabel Cristina Pinheiro de; Costa, Antônio de Lisboa Lopes
Rev. odontol. UNESP, vol.39, n5, p.311-315, 2010
Abstract
Low-grade polymorphous adenocarcinoma (PLGA) is a malignant neoplasm featuring low aggressiveness and almost exclusively originated from minor salivary glands. In the oral cavity, the palate is the most common site for PLGA development and its typical presentation is that of an indolent growth that may be painful or even ulcerated. In this manuscript we report an additional case of PLGA that shared clinical and histological features with the pleomorphic adenoma, and discuss the main aspects for its correct diagnosis.
Keywords
Malignant neoplasm, salivary gland, palate
Resumo
O adenocarcinoma polimorfo de baixo grau (APBG) é uma neoplasia maligna de baixo nível de agressividade, que ocorre quase exclusivamente em glândulas salivares menores. Na cavidade oral, o palato é a localização mais comum para o APBG e sua apresentação típica é de crescimento indolente, ocasionalmente doloroso ou ulcerado. Este manuscrito objetivou relatar um caso adicional de APBG, que apresentou características clínicas e histológicas semelhantes àquelas do adenoma pleomórfico na biópsia incisional, bem como discutir os aspectos principais para o seu correto diagnóstico.
Palavras-chave
Neoplasia maligna, glândula salivar, palato
Referências
1. Neville BW, Damm DD, Allen CM, Bouquot JE. Patologia oral e maxilofacial. 3ª ed. Rio de Janeiro: Elsevier; 2009.
2. Costa CMMS, Bonilha FJC, Bagnato NJ, Pimentel PAG. Caso clínico de adenocarcinoma de células acinares em região de parótida. Rev Bras Patol Oral. 2005; 4(1): 32-7.
3. Toida M, Shimokawa K, Makita H, Kato K, Kobayashi A, Kusunoki Y, et al. Intraoral minor salivary gland tumors: a clinicopathological study of 82 cases. Int J Oral Maxillofac Surg. 2005; 34: 528-32.
4. Pogodzinski MS, Sabri AN, Lewis JE, Olsen KD. Retrospective study and review of polymorphous low-grade adenocarcinoma. Laryngoscope. 2006; 116: 2145-9.
5. Asioli S, Marucci G, Ficarra G, Stephens M, Foschini MP, Ellis IO, et al. Polymorphous adenocarcinoma of the breast: report of three cases. Virchows Arch. 2006; 448(1): 29-34.
6. Beltran D, Faquin WC, Gallagher G, August M. Selective immunohistochemical comparison of polymorphous low-grade adenocarcinoma and adenoid cystic carcinoma. J Oral Maxillofac Surg. 2006; 64: 415-23.
7. Epivatianos A, Poulopoulos A, Dimitrakopoulos I, Andreadis D, Nomikos A, Vlahou S, et al. Application of α-smooth muscle actin and c-kit in the differential diagnosis of adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma. Oral Oncol. 2007; 43: 67‑76.
8. Ferrazzo KL, Martins-Neto M, dos Santos E, dos Santos Pinto D, de Sousa SO. Differential expression of galectin-3, β-catenin, and cyclin D1 in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands. J Oral Pathol Med. 2009; 38: 701-7.
9. Hunter JB, Smith RV, Brandwein-Gensler M. Low-grade papillary adenocarcinoma of the palate: the significance of distinguishing it from polymorphous low-grade adenocarcinoma. Head and Neck Pathol. 2008; 2: 316-23.
10. Kämmerer PW, Kreft A, Toyoshima T, Al-Nawas B, Klein MO. Misleading initial histological diagnosis of a polymorphous low-grade adenocarcinoma in situ ex pleomorphic adenoma—a case report. Oral Maxillofac Surg. 2009; 13: 99-103.
11. Yih WY, Kratochvil FJ,. Stewart JC. Intraoral minor salivary gland neoplasms: review of 213 cases. J Oral Maxillofac Surg. 2005; 63: 805‑10.
12. Ferrazzo KL, Alves SM Jr, Santos E, Martins MT, de Sousa SM. Galectin-3 immunoprofile in adenoid cystic carcinoma and polymorphous low-grade adenocarcinoma of salivary glands. Oral Oncol. 2007; 43: 580-5.
13. Gupta R, Gupta K, Gupta R. Polymorphous low-grade adenocarcinoma of the tongue: a case report. J Med Case Reports. 2009; 3: 9313.
14. Penner CR,Folpe AL, Budnick SD. C-kit expression distinguishes salivary gland adenoid cystic carcinoma from polymorphous low-grade adenocarcinoma. Mod Pathol. 2002; 15: 687-91.
15. Vasconcellos LMR, Silveira VAS, Rosa LEB, Cavalcante ASR, Carvalho YR. Immunohistochemistry as a fundamental tool for the differential diagnosis of polymorphous low-grade adenocarcinoma. Quintessence Int. 2006; 37: 565-73.
16. Curran AE, Allen CM, Beck FM, Damm DD, Murrah VA. Distinctive pattern of glial fibrillary acidic protein immunoreactivity useful in distinguishing fragmented pleomorphic adenoma, canalicular adenoma and polymorphous low grade adenocarcinoma of minor salivary glands. Head and Neck Pathol. 2007; 1(1): 27-32.
17. Castle JT, Thompson LDR, Frommelt RA, Wenig BM, Kessler HP. Polymorphous low-grade adenocarcinoma. A clinicopathologic study of 164 cases. Cancer. 1999; 86: 207-19.
18. Lagunas JG, Caparrós CA, Escofet GV, Redecilla PH, Martin GR. Adenocarcinoma polimorfo de bajo grado de fosa nasal. Med Oral Patol Oral Cir Bucal. 2005; 10: 367-70.
19. Perez-Ordonez B, Linkov I, Huvos AG. Polymorphous low-grade adenocarcinoma of minor salivary glands: a study of 17 cases with emphasis on cell differentiation. Histopathology. 1998; 32: 521-9.
Facebook
Google+
Twitter
LinkedIn
Mendeley
StumbleUpon
CiteULike
Reddit
Email