Revista de Odontologia da UNESP
https://revodontolunesp.com.br/article/588018097f8c9d0a098b4a39
Revista de Odontologia da UNESP
Original Article

Influência de fatores genéticos na etiopatogênese da doença periodontal

Influences of genetic factors in the etiopathogenesis of periodontal disease

Kim, Y.J.; Viana, A.C.; Scarel-Caminaga, R.M.

Downloads: 10
Views: 1258

Resumo

a doença periodontal (DP) tem caráter multifatorial pois a infecção por microrganismos periodontopatogênicos que leva à inflamação e à destruição do periodonto é modulada pela resposta imune do hospedeiro, a qual é influenciada por hábitos como o fumo. Fatores relacionados ao hospedeiro no contexto da DP têm sido bastante estudados nos últimos anos, principalmente no que se refere à imunogenética, fato que motivou esta revisão da literatura, que teve como objetivo comentar a influência que fatores genéticos podem desempenhar na etiopatogênese da DP, dando ênfase aos polimorfismos genéticos. O levantamento bibliográfico foi realizado nas bases de dados Bireme e PubMed utilizando-se os termos "Periodontite, Genética e Polimorfismos". Estudos sobre genética humana foram selecionados de forma a apresentar relação positiva ou negativa de fatores genéticos importantes, como polimorfismos, na DP. Concluiu-se pelos crescentes trabalhos na área que, apesar de ser inegável a influência genética na DP, ainda são necessários muitos outros estudos para melhor compreender esse mecanismo.

Palavras-chave

Periodontite, polimorfismos, genética

Abstract

periodontal diseases (PD) encompass multifactorial diseases due to the infection caused by periodontopathogenic microorganisms resulting in inflammation and periodontal destruction, are modulated by the host response. The immune response is influenced by host habits such as smoking. Important host factors regarding PD have been investigated in the last years, especially in immunogenetics. The aim of this literature review was to comment about genetic factors that might influence periodontal diseases. A search of Bireme and PubMed data bases was performed using terms like “Periodontitis, Genetics and Polymorphisms”. Important studies focusing on human genetics in individuals with periodontitis were selected to demonstrate positive and negative relationship between genetics factors, like polymorphisms, and PD. It can be concluded, considering the crescent number of studies in this area, that PD is influenced by genetic factors, although more researches are necessary to better understand which mechanisms are involved in this process.

Keywords

Periodontitis, polymorphisms, genetics

References



1. Hart AC. Genetic considerations of risk in human periodontal disease. Curr Opin. Periodontol. 1994;3:3‑11.

2. Susin C, Valle P, Oppermann RV, Haugejorden O, Albandar JM. Occurrence and risk indicators of in creased probing depth in an adult Brazilian population. J Clin Periodontol. 2005;32:123-9.

3. Cohen DW, Slavkin HC. Periodontal disease and systemic disease. In: Rose LF, Genco RJ, Cohen DW, Mealey BL. Periodontal medicine. Hamilton: B.C. Decker; 2000. p.2.

4. Flemmiig T. Periodontitis. Ann Periodontol. 1999;4:32-7.

5. Page RC, Schroeder HE. Pathogenesis of inflammatory periodontal disease. A summary of current work. Lab Invest. 1976;33:235-49.

6. Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL. Microbial complexes in subgingival plaque. J Clin Periodontol. 1998;25:134-44.

7. Okada H, Murakami S. Cytokine expression in periodontal helth and disease. Crit Rev Oral Biol Med. 1998;9:248-66.

8. Tonetti MS, Mombelli A. Early onset periodontitis. In: Lindhe J, Karring T, Lang NP, editors. Clinical periodontology and implant dentistry. 3rd ed. Copenhagen: Munksgaard ; 1997. p. 227-57.

9. Kornman KS, Page RC, Tonetti MS. The host response to the microbial challenge in periodontitis: assembling the players. Periodontol 2000. 1997;14:33-53.

10. Loe H. Periodontology in the past 20 years. Tandlaegebladet. 1986;90(18):788-94.

11. Johnson GK, Slach NA. Impact of tobacco use on periodontal status. J Dent Educ. 2001;65:313-21.

12. Mealy BL. Diabetes and periodontal disease: two sides of a coin. Compend Contin Educ Dent. 2000;21:943-6.

13. Linden GJ, Mullally BH, Freeman R. Stress and the progression of periodontal disease. J Clin Periodontol. 1996;23:675-80.

14. Shen EC, Gau CH, Hsieh YD, Chang CY, Fu E. Periodontal status in post-menopausal osteoporosis: a preliminary clinical study in Taiwanese women. J Chin Med Assoc. 2004;67:389-93.

15. Schenkein HA. Finding genetic risk factors for periodontal diseases: is the climb worth the view? Periodontol 2000. 2002;30:79-90.

16. Corey LA, Nance WE, Hofstede P, Schenkein HA. Self-reported periodontal disease in a Virginia twin population. J Periodontol. 1993;64:1205-8.

17. Michalowicz BS, Aeppli, D, Virag, JG, Klump DG, Hinrichs JE, Segal NL, et al. Periodontal findings in adults twins. J Periodontol. 1991;62:293-9.

18. Michalowicz BS, Diehl SR, Gunsolley JC, Sparks BS, Brooks CN, Koertge TE, et al. Evidence of a substancial genetic basis for risk of adult periodontitis. J Periodontol. 2000;71:1699-707.

19. Michalowicz BS, Wolf LF, Klump D, Hinrichs JE, Aeppli DM, Bouchard TJJ, et al. Periodontal bacteria in adult twins. J Periodontol.1999;70:263-73.

20. Boughman JA, Astemborski JA, Suzuki JB. Phenotypic assessment of early onset periodontitis in sibships. J Clin Periodontol.1992;19:233-9.

21. Trevilatto PC, Tramontina VA, Machado MA, Goncalves RB, Sallum AW, Line SR. Clinical, genetic and microbiological findings in a Brazilian family with aggressive periodontitis. J Clin Periodontol. 2002;29:233-9.

22. Marazita ML, Burmeister JA, Gunsolley JC, Koertge TE, Lake K, Schenkein HA. Evidence for autosomal dominat inheritance and race-specific heterogeneity in early-onset periodontitis. J Periodontol. 1994;65:623-30.

23. Borges-Osório MR, Robinson, WM. Genética humana. 2a ed. Porto Alegre: Artmed; 2001.

24. Shapira L, Wilensky A, Kinane DF Effect of genetic variability on the inflammatory response to periodontal infection. J Clin Periodontol. 2005;32(Suppl 6):72-86.

25. Tchetverikov I, Lohmander LS, Verzijl N, Huizinga TW, TeKoppele JM, Hanemaaijer R, et al. MMP protein and activity levels in synovial fluid from patients with joint injury, inflammatory arthritis, and osteoarthritis. Ann Rheum Dis. 2005;64:694-8

26. Tsiavou A, Hatziagelaki E, Chaidaroglou A, Manginas A, Koniavitou K, Degiannis D, et al. TNF-alpha, TGF-beta1, IL-10, IL-6, gene polymorphisms in latent autoimmune diabetes of adults (LADA) and type 2 diabetes mellitus. J Clin Immunol. 2004; 24:591-9.

27. McCarron SL, Edwards S, Evans PE, Gibbs R, Dearnaley DP, Dowe A, et al. Influence of cytokine gene polymorphisms on the development of prostate cancer. Cancer Res. 2002;62:3369-72.

28. Hobbs K, Negri J, Klinnert M., Rosenwasser LJ, Borish, L. Interleukin-10 and Transforming growth factor-β promoter polymorphisms in allergies and asthma. Am J Resp Crit Car Med.1998;158:1958-62.

29. Hajeer AH, Lazarus M, Turner D, Mageed RA, Vencovsky J, Sinnott P, et al. IL-10 gene promoter polymorphisms in rheumatoid arthritis. Scand J Rheumatol. 1998;27:142-5.

30. Lazarus M, Hajeer AH, Turner D, Sinnott P, Worthington J, Ollier WE, et al. Genetic variation in the interleukin 10 gene promoter and systemic lupus erythematosus. J Rheumatol. 1997;24:2314-7.

31. McGuire MK, Nunn ME. Prognosis versus actual outcome. IV. The effectiveness of clinical parameters and IL-1 genotype in accurately predicting prognoses and tooth survival. J Periodontol. 1999;70:49-56.

32. Gore EA, Sanders JJ, Pandey JP, Palesch Y, Galbraith GM. Interleukine-1beta +3953 allele 2: association with disease status in adult periodontitis. J Clin Periodontol. 1998;25:781-5.

33. Pociot F, Molvig J, Wogensen L, Worsaae H, Nerup J. A TaqI polymorphism in the human interleukin-1 beta (IL-1 beta) gene correlates with IL-1 beta secretion in vitro. Eur J Clin Invest. 1992;22:396-402.

34. Cullinan MP, Westerman B, Hamlet SM, Palmer JE, Faddy MJ, Lang NP, et al. A longitudinal study of interleukin-1 gene polymorphisms and periodontal disease in a general adult population. J Clin Periodontol. 2001;28:1137-44.

35. Laine ML, Farre MA, Gonzalez G, van Dijk LJ, Ham AJ, Winkel EG, Crusius JB, et al. Polymorphisms of the interleukin-1 gene family, oral microbial pathogens, and smoking in adult periodontitis. J Dent Res. 2001;80:1695-9.

36. Armitage GC, Wu Y, Wang HY, Sorrell J, di Giovine FS, Duff GW. Low prevalence of a periodontitis-associated interleukin-1 composite genotype in individuals of Chinese heritage. J Periodontol. 2000;71:164-71.

37. Parkhill JM, Henning BJ, Chapple IL, Heasman PA, Taylor JJ. Association of interleukin-1 gene polymorphisms with early-onset periodontitis. J Clin Periodontol. 2000;27:682-9.

38. Tai H, Endo M, Shimada Y, Gou E, Orima K, Kobayashi T, Yamazaki K, et al. Association of interleukin-1 receptor antagonist gene polymorphisms with early onset periodontitis in Japanese. J Clin Periodontol. 2002;29:882-8.

39. Trevillato PC, Sallum AW, Line SRP. Diagnóstico molecular da doença periodontal. Rev Assoc Paul Cir Dent. 2001;5:100-3.

40. Scarel-Caminaga RM, Trevilatto PC, Souza AP, Brito RB, Camargo LE, Line SR. Interleukin 10 gene promoter polymorphisms are associated with chronic periodontitis. J Clin Periodontol. 2004;31:443-8.

41. Komatsu Y, Tai H, Galicia JC, Shimada Y, Endo M, Akazawa K, et al. Interleukin-6 (IL-6)--373 A9T11 allele is associated with reduced susceptibility to chronic periodontitis in Japanese subjects and decreased serum IL-6 level. Tissue Antigens. 2005;65:110-4.

42. Folwaczny M, Glas J, Torok HP, Tonenchi L, Paschos E, Bauer B, et al. Polymorphisms of the interleukin‑18 gene in periodontitis patients. J Clin Periodontol. 2005;32:530-4.

43. Shapira L, Stabholz A, Rieckmann P, Kruse N. Genetic polymorphism of the tumor necrosis factor (TNF)-alpha promoter region in families with localized early-onset periodontitis. J Periodontal Res. 2001;36:183-6.

44. Galbraith GM, Steed RB, Sanders JJ, Pandey JP. Tumor necrosis factor alpha production by oral leukocytes: influence of tumornecrosis factor genotype. J Periodontol. 1998;69:428-33.

45. Scarel-Caminaga RM, Trevilatto PC, Souza AP, Brito Jr RB, Line, SRP. Investigation of an IL-2 polymorphism in patients with different levels of chronic periodontitis. J Clin Periodontol. 2002;29:587-91.

46. Trevilatto PC, Scarel-Caminaga RM, Brito Jr RB, Souza AP, Line SRP. Polymorphism at position –174 of IL-6 gene is associated with susceptibility to chronic periodontitis. J Clin Periodontol. 2003;30:438-42.

47. de Souza AP, Trevilatto PC, Scarel-Caminaga RM, Brito Jr RB, Line SRP. Analysis of the MMP-9 (C-1562 T) and TIMP-2 (G-418C) gene promoter polymorphisms in patients with chronic periodontitis. J Clin Periodontol. 2005;32:207-11.

48. Scarel-Caminaga RM, Trevilatto PC, Souza AP, Brito RB Jr, Line SR. Investigation of IL4 gene polymorphism in individuals with different levels of chronic periodontitis in a Brazilian population. J Clin Periodontol. 2003;30:341-5.

49. Pontes CC, Gonzales JR, Novaes Jr AB, Taba Jr M, Grisi MFM, Michel J, et al. Interleukin-4 gene polymorphism and its relation to periodontal disease in a Brazilian population of African heritage. J Dent. 2004;32:241-6.

50. Michel J, Gonzales JR, Wunderlich D, Diete A, Herrmann JM, Meyle J. Interleukin-4 polymosphism in early-onset periodontitis. J Clin Periodontol. 2001;28:483-8.

51. Kinane DF, Hodge P, Eskdale J, Ellis R, Gallagher G. Analysis of genetic polymorphisms at the interleukin-10 and tumour necrosis factor loci in early-onset periodontitis. J Periodontal Res. 1999;34:379-86.

52. Yamazaki K, Tabeta K, Nakajima T, Ohsawa Y, Ueki K, Itoh H, et al. Interleukin-10 gene promoter polymorphism in Japanese patients with adult and early-onset periodontitis. J Clin Periodontol. 2001;28:828-32.

53. Loos BG, John RP, Laine ML. Identification of genetic risk factors for periodontitis and possible mechanisms of action. J Clin Periodontol. 2005;32(Suppl 6):159-79.
588018097f8c9d0a098b4a39 rou Articles
Links & Downloads

Rev. odontol. UNESP

Share this page
Page Sections