Revista de Odontologia da UNESP
Revista de Odontologia da UNESP
Original Article

Utilização dos AINEs seletivos para COX-2 na quimioprevenção do câncer de cabeça e pescoço

The usage of COX-2 selective non-steroidal anti-inflammatory drugs in the Chemoprevention of head and neck cancer

Sousa, F.A.C.G.; Paradella, T.C.; Rocha, R.F.; Rosa, L.E.B.

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Por mais de uma década, vários estudos vêm sugerindo o envolvimento da COX-2 no processo de carcinogênese. Entretanto, se por um lado ainda muito pouco se sabe sobre a importância clínica desse fato, por outro torna-se cada vez mais evidente a eficácia dos AINEs seletivos para COX-2 tanto na prevenção quanto no tratamento de diversos tipos de câncer. Nesse contexto, o presente trabalho tem como objetivo realizar uma breve revisão a respeito da participação da COX-2 no tratamento de câncer de cabeça e pescoço, ressaltando a importância das drogas capazes de inibí-la na quimioprevenção da doença.


Câncer de cabeça e pescoço, antiinflamatórios não esteroidais, ciclooxigenase, quimioprevenção


Over decade, many studies have been suggesting the involvement of COX-2 in the carcinogenesis process. Little is known regarding the clinical importance of this factor. However, it becomes evident the effectiveness of COX-2 selective non-steroidal anti-inflammatory drugs to prevent and treat of various types of cancer. Within this context, the present study has the goal to briefly review the participation of COX-2 in both the head and neck cancer, highlighting the importance of COX-2 selective non-steroidal anti-inflammatory drugs in chemoprevention these diseases.


Head and neck cancer, COX-2 selective non-steroidal anti-inflammatory drugs, chemoprevention


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