Revista de Odontologia da UNESP
https://revodontolunesp.com.br/article/588017a77f8c9d0a098b4830
Revista de Odontologia da UNESP
Original Article

Citotoxicidade dos Materiais Dentários. Revisão de Literatura

Cytotoxicity of the dental materials. A literature review

Jorge, J.H.; Giampaolo, E.T.; Pavarina, A.C.

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Resumo

A biocompatibilidade dos materiais dentários tem sido avaliada por meio de estudos in vitro e in vivo e estudos clínicos em humanos. Os testes de citotoxicidade dos materiais dentários são considerados relativamente simples, reproduzíveis, efetivos e controlados. Diferentes parâmetros que avaliam a citotoxicidade dos materiais odontológicos podem ser utilizados para monitorar os efeitos citotóxicos, como a inibição do crescimento celular, a citólise, as modificações na membrana ou no citoplasma e as alterações na atividade metabólica. Os resultados dos testes iniciais de citotoxicidade apresentam limitações quanto à sua correlação direta com situações clínicas, não podendo ser extrapolados para seres humanos. Entretanto, a utilização de diferentes métodos proporciona informações mais completas sobre a citotoxicidade do material testado.

Palavras-chave

Citotoxicidade, cultura de células, materiais dentários.

Abstract

Biocompatibility of dental materials has been evaluated by in vitro and in vivo studies and human clinical studies. Testing of dental materials by cell culture methods are relatively simple to perform, reproducible, cost-effective and can be carefully controlled. Different parameters are used to monitor cytotoxic effects of the dental materials, such as inhibition of cell growth, cytolysis, the effects on membrane or cytoplasmic markers and changes in metabolic activity. The data of cytotoxicity test cannot necessarily be extrapolated to clinical scenarios. However, the use of different assessment methods provides more complete information on the toxicity of the material under analysis.

Keywords

Cytotoxicity, cell culture, dental materials

References



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