Os resultados do estudo sobre o efeito da imunossupressão com ciclosporina sobre transplantes dentários homógenos permitiram concluir que: a) a ciclosporina foi efetiva na diminuição do infiltrado inflamatório ao nível do conjuntívo da mucosa gengival, do ligamento periodontal e fundo alveolar; b) houve marcante redução na ocorrência de reabsorções cemento-dentínárias e anquilose alvéolo-dental; c) houve deposição cementária sobre superfícies radiculares não reabsorvíveis; d) não foram observadas calcificações semelhantes a tecido ósseo ao nível dos terços médios e apical da polpa dental e e) não se desenvolveram estruturas semelhantes a germes dentais.

Thirty-six male albino rats were used to study the effect of cyclosporin on homogenous tooth transplantation. The animals were divided into two groups. The animals in Group I received homogenous transplantation of the right upper incisor and daily intraperitoneal injections of 0,4 ml of saline. The animals in Group II received the same surgical procedures and a daily intraperitoneal injection of a cyclosporin solution (10 mg/kg of body weight/day). The animals were sacrificed after 10, 30 and 60 days. Histological results showed that cyclosporin induced a marked reduction on the occurrence of inflammatory root resorption. The resorption areas that did occur were repaired by newly formed cement. Calcified masses in the dental pulp were not observed in the treated group. Dental germ-like structures were absent at the apical region in the treated group.