Revista de Odontologia da UNESP
https://revodontolunesp.com.br/article/5880177b7f8c9d0a098b4752
Revista de Odontologia da UNESP
Original Article

Estudo histomorfológico de glândulas submandibulares de rato submetidas a doses baixas de radiação X

Histomorphological study of submandibulary glands of rat submitted to low dosage of x-radiation

Navarro, C.M.; Chan, C.; Onofre, M.A.; Cordeiro, R.C.L.; Raveli, D.B.

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Resumo

Realizou-se estudo histomorfológico de glândulas submandibulares de ratos submetidas a doses baixas de radiação X, tendo em vista o não conhecimento da dose mínima capaz de produzir reações celulares e a escassez de trabalhos na literatura empregando doses consideradas baixas. O corpo dos animais foi recoberto por lâmina de chumbo perfurada na região cervical onde se localizam as glândulas submandibulares, que foram expostas a 1,80 Gy de radiação X em dose única. Após 24, 48, 72 horas, 7, 14 e 21 dias, as glândulas foram removidas e processadas para estudos em microscopia de luz, tendo sido observadas alterações degenerativas discretas e pleomorfismo nuclear, principalmente nos primeiros três períodos experimentais.

Palavras-chave

Glândulas salivares, radiação, ratos

Abstract

The minimal dosage of X-ray that is likely to induce cellular alterations is unknown and there are just a few reports with low dosage in odontologic literature. The authors developed a histomorphological analysis of the submandibulary glands of rat that received low dosage of X-radiation. The body of the animals was covered with a lead lamin leaving the cervical area uncovered. The submandibular glands were exposed to 1,80 Gy of X-radiation in a single dose. After 24, 48, 72 hours, 7, 14 and 21 days the glands were excised, fixed and prepared for analysis in light microscopy. Mild degenerative changes and nuclear pleomorfism, mainly on the first three experimental periods were observed.

Keywords

Salivary glands, radiation, rats
5880177b7f8c9d0a098b4752 rou Articles
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Rev. odontol. UNESP

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