Camundongos fêmeas prenhes foram injetadas no 14º dia de gestação com 200 mg/kg de peso corporal de Ivermectina. Os filhotes foram sacrificados 1, 5 e 10 dias após o nascimento, e as cabeças processadas histologicamente para análise do palato e dos germes dentais. Os resultados não mostraram diferenças no desenvolvimento, pois o palato estava fechado e os germes dentais dos animais tratados eram semelhantes aos dos animais controle. Desse modo, nas condições experimentais deste trabalho, a Ivermectina não se mostrou tóxica às células, permitindo um desenvolvimento das estruturas analisadas com características compatíveis com as encontradas nos animais controle e com as descritas na literatura.

Female mice at the 14th day of the gestational period were inject with a single dose of 200 mg/kg body weight of ivermectin. The offspring were sacrified 1, 5 and 10 days after birth. Their heads were submitted to a histological procedure for analysis of palate closure and tooth germs development. The results did not show differences of the development, that is, the palate was closed and the tooth germs of both treated and control groups presented very similar aspects. Thus, under the experimental conditions used here, the ivermectin did not show cell toxicity once that it was found a development of the analysed structures compatible with those found in the control group and with those described in the literature.