Avaliação de membranas de colágeno com diferentes períodos de cross-linkage. Estudo histológico em subcutâneo do rato
Evaluation of collagen membranes with different cross-linkage periods. Subcutaneous histologic study in rat
Cancian, D.C.J.; Marcantonio Jr., E.; Marcantonio, R.A.C.; Góissis, G.; Lia, R.C.C.; Carvalho, W.M.
Rev. odontol. UNESP, vol.21, nÚnico, p.181-190, 1992
Resumo
Foram avaliadas, histologicamente, 3 membranas de colágeno com periodos diferentes de tratamento por glutaraldeido a 0,05% (8, 22 e 28 horas). Os materiais foram implantados em tecido subcutâneo de ratos por 3, 7, 15, 30 e 60 dias. A análise histológica mostrou: padrão irritativo semelhante para os 3 grupos; os materiais sofreram reabsorção completa para o grupo I (8 h) e incompleta para os grupos II e III (22 e 28 h) após 60 dias; boa aceitação biológica; o material (colágeno) é promissor para confecção de membranas periodontais reabsorviveis.
Palavras-chave
Colágeno, toxicidade, materiais biocompatíveis, doenças periodontais
Abstract
The collagen membranes were implanted in subcutaneos tissue of rats after treated with 0.05% glutaraldeido for different periods (8, 22, 28 h). The animals were sacrificed after 3, 7, 15, 30, and 60 days. HistologicaI analysis showed: similar irritative pattems for the thre groups; resorption for all materials tested, complete in group I (8 h) and incomplete for groups II and III (22 and 28 h) after 60 days; good biological acceptance. Collagen is a promissing material to be used for making resorbable periodontal membranes.
Keywords
Collagen toxicity, biocompatible materials, periodontal diseases
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