Thirty six remale mice were injected on the 12th day or the gestational period with 02 ml of distilled watter (control group) or of an acqueous solution containing either 30 mg/Kg or 50 mg/Kg or body weight or cyclophosphamide (treated group). The animal were killed at 24, 48, 72, 96 and 120 hours after the injection and 3 days after birth. It was verified that cyclophosphamide interferes on the tooth germ development and that this effect is in directly ratio of the doses used.

36 camundongos fêmeas foram injetadas, no 12º dia de prenhez, com 0,2 ml de água destilada (grupo controle) ou de solução aquosa com 30 mg/kg ou 50 mg/kg de peso de ciclofosfamida (grupo tratado). Os animais foram sacrificados 24, 48, 72, 96 e 120 horas após a injeção e 3 dias após o parto. Verificou-se que a ciclofosfamida interfere no desenvolvimento do germe dental de forma diretamente proporcional à dose empregada.