Morphological alterations of the rat submandibular gland caused by lesion of the ventromedial nucleus of the hypothalamus
Alterações morfológicas da glândula submandibular do rato produzidas por lesão do núcleo ventromedial do hipotálamo
Renzi, A.; Utrilla, L.S.; Camargo, L.A.A.; Saad, W.A.; Luca Júnior, L.A.; Menani, J.V.; Roslindo, N.C.
Rev. odontol. UNESP, vol.18, nÚnico, p.157-164, 1989
Abstract
The morphological characteristics of the rat submandibular gland were studied different of times (5, 10, 20, 40, and 90 days) after lesion of the ventromedial nucleus of the hypothalamus. The structural arrangement of the submandibular gland was the same in rats with lesion of the ventromedial nucleus and in control or sham-lesioned animals. ln the first group, However, the septa were narrow, this impairing the definition of the lobular compartments. Parenchymal alterations were quite evident in lesioned animals, with acinar hypotrophy and increased numbers of granulose ducts. The remaining submandibular components, however, did not show morphological alterations when compared to those of control animals. ln summary, lesion of the ventromedial nucleus of the hypothalamus produces the following changes in the rat submandibular gland: 1) decreased glandular masses, 2) acinar hypotrophy, and 3) increased numbers of granulose ducts.
Keywords
Submandibular gland, ventromedial nucleus of hypothalamus, hypothalamic lesions
Resumo
As características morfológicas da glândula submandibular de ratos foram estudadas em diferentes períodos de tempo (5, 10, 20, 40 e 90 dias) após a lesão do núcleo ventromedial do hipotálamo. O arranjo estrutural da glândula submandibular foi o mesmo em ratos com lesão do núcleo ventromedial e nos ratos controle ou com lesão fictícia. No primeiro grupo, entretanto, o septo estava estreitado, dificultando a definição dos compartimentos lobulares. Alterações do parênquima foram bastante evidentes nos ratos lesados, com hipotrofia acinar e aumento no número de duetos granulosos. Os componentes submandibulares restantes, entretanto, não apresentaram alterações quando comparados com aqueles dos animais controles. Em resumo, a lesão do núcleo ventromedial do hipotálamo produz as seguintes mudanças na glândula submandibular do rato: 1) diminuição da massa glandular; 2) hipotrofia acinar; e 3) aumento no número de duetos granulosos.
Palavras-chave
Glândula submandibular, núcleo ventromedial do hipotálamo, lesão hipotalâmica
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