Efeito da extirpação das glândulas salivares maiores, atadura de seus ductos e da administração de tiroxina sobre a erupção e o crescimento dental em ratos
The effect of salivary glands extirpation, duct ligation, and thyroxine administration on the emergence time and eruption rate of teeth in rats
D'Antonio, G.M.; Madeira, M.C.
Rev. odontol. UNESP, vol.14, nÚnico, p.85-95, 1985
Resumo
Motivados pela possÃvel interação funcional das glândulas tireóide e salivares e também pela ação das mesmas sobre o desenvolvimento dental, os autores planejaram uma pesquisa para verificar o efeito da cirurgia das glândulas salivares (ablação total e ligadura dos ductos) e da administração de tiroxina sobre o crescimento do incisivo e a erupção do molar. Quarenta e oito ratos albinos, machos, foram divididos em seis grupos de oito animais cada: Controle; Tiroxina; Ducto-atado; Salivariadenoprivo; Ducto-atado + tiroxina; Salivariadenoprivo + tiroxina. Com exceção dos animais do grupo controle, todos os demais foram operados aos 15 dias de vida e/ou tratados com tiroxina a partir da mesma data. A sialoadenectomia e a ducto-atadura retardaram a época da erupção do terceiro molar, mas não alteraram a velocidade de crescimento do incisivo. A tiroxina, na dose de 0,5 mcg por dia, corrigiu a época da erupção do terceiro molar, alterada pela sialoadenectomia e pela ducto-atadura.
Palavras-chave
Glândula salivar, sialoadenectomia, tiroxina, erupção dental, crescimento dental
Abstract
The possible functional interaction between the thyroid and salivary glands and the action of these glands upon the dental development, motivated the authors to search out the effect of salivary glands extirpation and/or duct-ligation and thyroxine injection on the incisor growth and molar emergence time. Forty-eight male albino rats were divided into six groups of eight animals each: Control, Thyroxine; Duct-Ligated; Salivariadenectomized; Duct-Ligated + Thyroxine; Salivariadenectomized + Thyroxineo The surgery was performed on the 15th day of life and thyroxine was given from 15th through the 38th day. The sialoadenectomy and duct-ligation decreased the emergence time of the third molar, but did not change the eruption rate of the continuous growing incisor tooth. The daily injection of thyroxine, in a dosage of 0.5 mcg, corrected the emergence time of the molar altered by sialoadenectomy and duct-ligation.
Keywords
Salivary gland, sialoadenectomy, thyroxine, dental eruption, dental growth
References
I. ARCIERI, R. M. - Distribuição do glicogênio
nos ameloblastos, odontoblastos e epitélio bucal
de ratos nascidos de mães salivariadenoprivos.
Estudo histoquÃmico. Araçatuba, Fac.
Odont. Araçatuba, UNESP, 1973. (Tese Doutoramento).
2. ARVY, L.; DEBRAY, C. H. & GABE, M. Action de la thiourée sur la glande sous maxillaire du rat albino. Compt. Rend. Soe. Biol., 144: 111-3, 1950.
3. BAUME, L. J. & BECKS, H. - Hormonal control of growth and eruption of upper rat incisor. I. The effect of thyroidectomy at birth and the response to growth hormone and thyroxin. J. dento Res., 32: 693-4, 1953.
4. BAUME, L. J.; BECKS, H.; RA Y, J. C. & EVANS, H. M. - Hormonal control of tooth eruption. I. The effect of thyroidectomy on upper rat incisor and the response to growth hormone, thyroxin, or the combination of both. J. dento Res., 33: 80-90, 1954.
5. BROWN, W. A. B.; McCANCE, R. A. & FORD, E. H. R. - The effect of severe undernutrition on the development of the skull and teeth of growing pigs. J. dento Res., 4(); 1.289, 1961.
6. CHEYNE, V. D. - A description of the salivary glands of the rat and a procedure for their extirpation. J. dento Res., 18: 457-66, 1939.
7. COHEN, S. - Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the newborn animal. J. biol. Chem., 237: 1.555-62, 1962.
8. D'ANTONIO, G. M. & MADEIRA, M. C. The effect of salivary gland extirpation, duct ligation, and thyroxine administration upon body weight in rats. Rev. Odont. UNESP, 13: 99-104, 1984.
9. DOMM, L. V. & WELLBAND, W. A. - The effect of adrenalectomy, thyroidectomy, thyroadrenalectomy on eruption rate of incisores in female rats. Proe. Soe. exp. Biol. N. Y., 107: 268-71,1961.
10. FAWCETT, D. M. & KIRKWOOD, S. - Role of salivary glands in extrathyroidal iodine metabolism. Science, 120: 547-8, 1954. II. FLEMING, H. S. - Parotin and growth centers of femurs and incisors in mice. 1. dento Res., 38: 374-85, 1959.
12. FUKUSHIMA, M. - The effect of salivary hormone upon the development of dental tissue. Trans. Soe. Path. Jap., 3(); 245-59, 1940.
13. FUKUSHIMA, M. - The effect of salivary hormone upon the development of dental tissue. Trans. Soe. Path. Jap., 32: 293-4, 1942. 94
14. GARREN, L. & GREEP, R. O. - Effects of thyroid hormone and propylthiouracil on eruption rate of upper incisor teeth in rats. Proc. Soe. exp. Biol. Med., 90: 652-5, 1955.
15. HERZBERG, F. & SCHOUR, I. - Effects of thyroxine on rate of eruption and dentin apposition. J. dento Res., 2(); 276, 1940.
16. HETEM, S.; MADEIRA, M. c.; RULLI, M. A: & MARCHI, F. - Relationship between the number of rat Iittermates per dam and dentinogenesis. Buli. Tokyo dento CoII., 17: 57-60, 1976.
17. INADA, M. - Cárie experimental: polissacarÃdeos em glândulas salivares maiores, ductoatadas e remanescentes após dueto-atadura ou extirpação seletivas em ratos alimentados com ração cariogênica. Araçatuba, Fac. Odont. Araçatuba, UNESP, 1973 (Tese - Doutoramento).
18. no, Y. - Parotin: a salivary gland hormone. Ann. N. Y. A cad. Sei., 85: 228-310,1960.
19. no, Y. & MIZUTANI, A. - Studies on the salivary gland hormones. Report X II I - Purification of Parotin, the pH 5.4 precipitate from bovine parotid glands by fractional precipitation with sodium sulfate. J. phar"". Soe. Jap., 72: 239-48, 1952.
20. JOHANNESSEN, L. B. - Effects on food intake, somatic growth and dentinogenesis in immature male albino rats of a low dose of propylthiouracil without, and together with, desiccated thyroid. Arch. oral Biol., II: 98397, 1966.
21. LACASSAGNE, A. - Dimorphisme sexuel de la glande sous maxillaire chez la sou ris. Compt. Rend. Soe. Biol., 133: 180-1, 1940.
22. LIMA, J. E. de O.; PINHEIRO, C. E.; PAVARINI, A. & MARQUES, A. L. V. - Influência das glândulas salivares no irrompimento, crescimento e calcificação dos dentes incisivos e molares de ratos. Estomat. Cult., 9: 161-6,
1975. •
23. LIVREA, G.; GIORGIANNI, C. & PICCIOTO, A. - Modification of continuous growth of incisors. VI - Thyroid and parathyroid action. iii. effects of thiroxine. iv. effects of parotidectomy. BoII. Soe. ital. Biol. sper., 40: 1.297-9, 1964.
24. MADEIRA, M. c.; HETEM, S. & RULLI, M. A. - Relationship between the number of rat littermates per dam and mandibular incisor growth. J. dento Res., 53: 634-6, 1974.
25. MADEIRA, M. c.; HETEM, S.; TAGLIAVINI, O. & MARCHI, F. - Relationship between the number of rat littermates per dam and emergence time of the third molar. J. dento Res., 50: 1.682, 1971.
26. MADEIRA, M. C. & PINHEIRO, C. E. - Influência de hormônios na erupção e no crescimento de dentes molares e incisivos de ratos. II. Ação da hidrocortisona e da insulina. A rq. Cento Est. Fac. Odont. UFMG, 5: 59-67, 1968.
27. MATSUDA, N. - On effects of a submaxillary gland extract upon calcification figure of rabbit dentine and bone. Gunma J. medo Sci., 4: 317-24,1955.
28. MIDDLEBURGH, H. - Hyperthyroidism and early eruption of teeth. Brit. dento J., 66: 2945,1939.
29. OGATA, A.; no, Y.; NOZAKI, Y.; OKABE, S.; OGATA, T. & ISHII, Z. - Chemical and pathological studies on the isolation of salivary hormone. Igaku - to Seibutsugaku, 5: 253-7, 1944.
30. OGATA, T. - The internal secretion of salivary gland. Endoer. jap., 2: 247-61,1955.
31. POLCZER, J. - A maradó fogak attõrésenek kesdete és a testi. Fejlettség Kõzõtti Kapcsolatokrõl. Fogorv Szemle, 58: 333-5, 1965.
32. RULLI, M. A. - Tecido de granulação cicatricial em ratos submetidos à extirpação de glândulas salivares: estudo morfológico e histoquÃmico. Rev. Fac. Odont. Araçatuba, 2: 17183, 1973.
33. SATO, T. - Effects of parotid gland extract upon calcification of dentin of rabbit. Gunma J. medo Sci., 2: 183-5, 1953.
34. SCHOUR, I. - NOYES'Oral histology and embriology. 8. a ed., Philadelphia, Lea & Febiger, 1953.
35. SHAFER, W. G.; CLARK, P. G.; BIXLER, D. & MUHLER, J. C. - Salivary gland function in rats. II. Effect of thyroid function on salivary f10w and viscosity. Proc. Soe. exp. Biol. Med., 98: 245-7,1958.
36. SHULMAN, J. - Causes and mechanisms of tooth eruption. A literature review. J. west. Soco Periodont., 24: 162-71, 1976/1977.
37. SNEDECOR, G. W. - Statistical methods. 5. a ed., Ames, Iowa State College Press, 1956.
38. STANDISH, S. M. & SHAFER, W. G. - Serial histologic effects of rat submaxillary and sublingual salivary gland duct and blood vessel Iigation. J. dento Res., 36: 866-79,1957.
39. TORTAMANO, N. - Hipertrofia da glândula submandibular do rato após amputações periódicas dos incisivos inferiores. Estudo estrutural e bioquÃmico. São Paulo, Fac. Odont. USP,
1974. (Tese - Livre-Docência).
40. WASE, A. W. & FENG, Y. S. L. - The effect of sialoadenectomy on thyroid activity. Nature, 177: 624-5,1956.
41. .WASE, A. W. & FENG, Y. S. L. Some salival'y-thyroid gland relationships. Acta Endocr., 23: 413-8,1956.
42. WELLS, H. & MUNSON, P. L. - Effect of thyroxine on the weight of submaxillary salivary glands. J. dento Res., 37: 55, 1958.
43. ZANNINI, O. - Rapport entre variations chronologiques de I'éruption dentaire et caracteres somatotypiques. Orthod. franç., 35: 519-30, 1964.
44. ZISKIN, D. E. & APPLEBAUM, E. - Effect of thyroidectomy and thyrotrophic hormone on the developing teeth in Rhesus monkeys. J. dento Res., 19: 304, 1940.
2. ARVY, L.; DEBRAY, C. H. & GABE, M. Action de la thiourée sur la glande sous maxillaire du rat albino. Compt. Rend. Soe. Biol., 144: 111-3, 1950.
3. BAUME, L. J. & BECKS, H. - Hormonal control of growth and eruption of upper rat incisor. I. The effect of thyroidectomy at birth and the response to growth hormone and thyroxin. J. dento Res., 32: 693-4, 1953.
4. BAUME, L. J.; BECKS, H.; RA Y, J. C. & EVANS, H. M. - Hormonal control of tooth eruption. I. The effect of thyroidectomy on upper rat incisor and the response to growth hormone, thyroxin, or the combination of both. J. dento Res., 33: 80-90, 1954.
5. BROWN, W. A. B.; McCANCE, R. A. & FORD, E. H. R. - The effect of severe undernutrition on the development of the skull and teeth of growing pigs. J. dento Res., 4(); 1.289, 1961.
6. CHEYNE, V. D. - A description of the salivary glands of the rat and a procedure for their extirpation. J. dento Res., 18: 457-66, 1939.
7. COHEN, S. - Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the newborn animal. J. biol. Chem., 237: 1.555-62, 1962.
8. D'ANTONIO, G. M. & MADEIRA, M. C. The effect of salivary gland extirpation, duct ligation, and thyroxine administration upon body weight in rats. Rev. Odont. UNESP, 13: 99-104, 1984.
9. DOMM, L. V. & WELLBAND, W. A. - The effect of adrenalectomy, thyroidectomy, thyroadrenalectomy on eruption rate of incisores in female rats. Proe. Soe. exp. Biol. N. Y., 107: 268-71,1961.
10. FAWCETT, D. M. & KIRKWOOD, S. - Role of salivary glands in extrathyroidal iodine metabolism. Science, 120: 547-8, 1954. II. FLEMING, H. S. - Parotin and growth centers of femurs and incisors in mice. 1. dento Res., 38: 374-85, 1959.
12. FUKUSHIMA, M. - The effect of salivary hormone upon the development of dental tissue. Trans. Soe. Path. Jap., 3(); 245-59, 1940.
13. FUKUSHIMA, M. - The effect of salivary hormone upon the development of dental tissue. Trans. Soe. Path. Jap., 32: 293-4, 1942. 94
14. GARREN, L. & GREEP, R. O. - Effects of thyroid hormone and propylthiouracil on eruption rate of upper incisor teeth in rats. Proc. Soe. exp. Biol. Med., 90: 652-5, 1955.
15. HERZBERG, F. & SCHOUR, I. - Effects of thyroxine on rate of eruption and dentin apposition. J. dento Res., 2(); 276, 1940.
16. HETEM, S.; MADEIRA, M. c.; RULLI, M. A: & MARCHI, F. - Relationship between the number of rat Iittermates per dam and dentinogenesis. Buli. Tokyo dento CoII., 17: 57-60, 1976.
17. INADA, M. - Cárie experimental: polissacarÃdeos em glândulas salivares maiores, ductoatadas e remanescentes após dueto-atadura ou extirpação seletivas em ratos alimentados com ração cariogênica. Araçatuba, Fac. Odont. Araçatuba, UNESP, 1973 (Tese - Doutoramento).
18. no, Y. - Parotin: a salivary gland hormone. Ann. N. Y. A cad. Sei., 85: 228-310,1960.
19. no, Y. & MIZUTANI, A. - Studies on the salivary gland hormones. Report X II I - Purification of Parotin, the pH 5.4 precipitate from bovine parotid glands by fractional precipitation with sodium sulfate. J. phar"". Soe. Jap., 72: 239-48, 1952.
20. JOHANNESSEN, L. B. - Effects on food intake, somatic growth and dentinogenesis in immature male albino rats of a low dose of propylthiouracil without, and together with, desiccated thyroid. Arch. oral Biol., II: 98397, 1966.
21. LACASSAGNE, A. - Dimorphisme sexuel de la glande sous maxillaire chez la sou ris. Compt. Rend. Soe. Biol., 133: 180-1, 1940.
22. LIMA, J. E. de O.; PINHEIRO, C. E.; PAVARINI, A. & MARQUES, A. L. V. - Influência das glândulas salivares no irrompimento, crescimento e calcificação dos dentes incisivos e molares de ratos. Estomat. Cult., 9: 161-6,
1975. •
23. LIVREA, G.; GIORGIANNI, C. & PICCIOTO, A. - Modification of continuous growth of incisors. VI - Thyroid and parathyroid action. iii. effects of thiroxine. iv. effects of parotidectomy. BoII. Soe. ital. Biol. sper., 40: 1.297-9, 1964.
24. MADEIRA, M. c.; HETEM, S. & RULLI, M. A. - Relationship between the number of rat littermates per dam and mandibular incisor growth. J. dento Res., 53: 634-6, 1974.
25. MADEIRA, M. c.; HETEM, S.; TAGLIAVINI, O. & MARCHI, F. - Relationship between the number of rat littermates per dam and emergence time of the third molar. J. dento Res., 50: 1.682, 1971.
26. MADEIRA, M. C. & PINHEIRO, C. E. - Influência de hormônios na erupção e no crescimento de dentes molares e incisivos de ratos. II. Ação da hidrocortisona e da insulina. A rq. Cento Est. Fac. Odont. UFMG, 5: 59-67, 1968.
27. MATSUDA, N. - On effects of a submaxillary gland extract upon calcification figure of rabbit dentine and bone. Gunma J. medo Sci., 4: 317-24,1955.
28. MIDDLEBURGH, H. - Hyperthyroidism and early eruption of teeth. Brit. dento J., 66: 2945,1939.
29. OGATA, A.; no, Y.; NOZAKI, Y.; OKABE, S.; OGATA, T. & ISHII, Z. - Chemical and pathological studies on the isolation of salivary hormone. Igaku - to Seibutsugaku, 5: 253-7, 1944.
30. OGATA, T. - The internal secretion of salivary gland. Endoer. jap., 2: 247-61,1955.
31. POLCZER, J. - A maradó fogak attõrésenek kesdete és a testi. Fejlettség Kõzõtti Kapcsolatokrõl. Fogorv Szemle, 58: 333-5, 1965.
32. RULLI, M. A. - Tecido de granulação cicatricial em ratos submetidos à extirpação de glândulas salivares: estudo morfológico e histoquÃmico. Rev. Fac. Odont. Araçatuba, 2: 17183, 1973.
33. SATO, T. - Effects of parotid gland extract upon calcification of dentin of rabbit. Gunma J. medo Sci., 2: 183-5, 1953.
34. SCHOUR, I. - NOYES'Oral histology and embriology. 8. a ed., Philadelphia, Lea & Febiger, 1953.
35. SHAFER, W. G.; CLARK, P. G.; BIXLER, D. & MUHLER, J. C. - Salivary gland function in rats. II. Effect of thyroid function on salivary f10w and viscosity. Proc. Soe. exp. Biol. Med., 98: 245-7,1958.
36. SHULMAN, J. - Causes and mechanisms of tooth eruption. A literature review. J. west. Soco Periodont., 24: 162-71, 1976/1977.
37. SNEDECOR, G. W. - Statistical methods. 5. a ed., Ames, Iowa State College Press, 1956.
38. STANDISH, S. M. & SHAFER, W. G. - Serial histologic effects of rat submaxillary and sublingual salivary gland duct and blood vessel Iigation. J. dento Res., 36: 866-79,1957.
39. TORTAMANO, N. - Hipertrofia da glândula submandibular do rato após amputações periódicas dos incisivos inferiores. Estudo estrutural e bioquÃmico. São Paulo, Fac. Odont. USP,
1974. (Tese - Livre-Docência).
40. WASE, A. W. & FENG, Y. S. L. - The effect of sialoadenectomy on thyroid activity. Nature, 177: 624-5,1956.
41. .WASE, A. W. & FENG, Y. S. L. Some salival'y-thyroid gland relationships. Acta Endocr., 23: 413-8,1956.
42. WELLS, H. & MUNSON, P. L. - Effect of thyroxine on the weight of submaxillary salivary glands. J. dento Res., 37: 55, 1958.
43. ZANNINI, O. - Rapport entre variations chronologiques de I'éruption dentaire et caracteres somatotypiques. Orthod. franç., 35: 519-30, 1964.
44. ZISKIN, D. E. & APPLEBAUM, E. - Effect of thyroidectomy and thyrotrophic hormone on the developing teeth in Rhesus monkeys. J. dento Res., 19: 304, 1940.
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