Influência de anestésicos no processo de reparo alveolar após anestesia terminal infiltrativa e irrigação alveolar. Estudo histológico em ratos
Influence of some anesthetics on the dental extraction wound healing. Histological study in rats
Saad Neto, M.; Callestini, E.A.; Okamoto, T.; Kuroki, M.
Rev. odontol. UNESP, vol.14, nÚnico, p.35-45, 1985
Resumo
Foi analisada a influência de alguns anestésicos no processo de reparo alveolar após anestesia terminal infiltrativa no palato e na região vestibular (fórnix do vestíbulo), acrescido da irrigação intra-alveolar. Concluem que a irrigação intra-alveolar com soluções anestésicas, com e sem vasoconstrictor, acrescida de anestesias terminais infiltrativas, altera a cronologia do reparo alveolar de forma mais acentuada do que a simples irrigação abundante do alvéolo. Essa alteração é agravada quando o anestésico contém vasoconstrictor. Os autores são de opinião que o uso da solução anestésica nestas condições é um fator predisponente e não causal da alveolite.
Palavras-chave
Extração dental, reparo alveolar, anestesia local, alveolite
Abstract
The aim of this paper was to analyse the wound healing of dental extraction in rats following intra-alveolar irrigation and terminal infiltrative anesthetics of palate and buccal region with some commercial dental anesthetic. Two groups of 190 male albino rats each were utilized; their right upper incisors were extracted and intra-alveolar irrigation with 1.4 ml of commercial dental anesthetics was employed in one group of rats. Intra-alveolar irrigation (1.4 ml) plus terminal infiltrative anesthetic for palate (0.04 ml) and vestibule fornix (0.12 ml) after postoperative periods of 1, 3, 6, 9, 15, 21, and 24 days. The sections of the obtained pieces were stained with hematoxylin and eosin for morphological study. According to the results obtained in the present papel it was possible to conclude that the chronological evolution of the dental extraction wound healing is delayed in presence of terminal infiltrative anesthesia and intra alveolar irrigation with the same anesthetics. These changes were aggravated with the useof anesthetic with vasoconstrictor. The anesthetic solution seems to be a predisponent factor and not a causative factor to provoke dry socket.
Keywords
Tooth extraction, wound healing, local anesthesia, dry socket
References
1. ACAYAGA, O.c. & OLAZÁBAL, R.A. Patologia, anatomia y fisiologia patológica buco dental. 4. ed. Buenos Aires, EI Ateneo, 1960.
2. ALLING, c.c. & KERR, D.A. - Trauma as a factor causing delayed repair of dental extractions sites. J. oral Surg., 15: 3-11, 1957.
3. BASTOS, J.B.P. - Medicina da Boca. 2. ed. Alfenas, 1967.
4. BECERRA. H.D. - Importancia de la resposta vascular en el quadro de la alveolitis. Acta odont. venez., 3:438-45.1967.
5. BERGER, A. - Exodoncia. Trad. J. Vilá y Torrent. Buenos Aires, Labor, 1934.
6. BERLOVE, I.J. Emergencies and complications. Chicago, Year Book Publ., 1959.
7. BIRN,H. - Fibrinolytic activity of alveolar bone in "dry socket". Acta odont. scand., 30: 2332, 1972.
8. BIRN, H. - Etiology and pathogenesis of fibrinolytic alveolitis ("dry socket"). In/. J. oral Surg.,2:211-67,1973.
9. CARVALHO, A.C.P. & OKAMOTO, T. Implantes intra-alveolares. Considerações sobre estudos experimentais. Rev. Ass. paul. Cirurg. Dent., 32: 273-9, 1978.
10. CARVALHO, A.C.P.; OKAMOTO, T. & SAAD NETO, M. - Reação do tecido conjuntivo subcutâneo a alguns anestésicos locais. Rev. Fac. Odont. Araça/uba, 5: 53-61, 1976.
11. D'ANTONIO, G.M. - Contaminação pós. exodôntica do alvéolo dental de ratos. Estudo microbioló~icoe histológico. Araçatuba, Fac. 44 Odont. Araçatuba, UNESP, 1984. (Tese Doutorado).
12. EICHHORN, J.H. & PETERKOFSKY, B. Local anesthetic - induced inhibition of colIagen secretion in cultured cells under conditions where microtubules are not depolymerized by theseagents. J. CeI/ 8io/., 81:26-42,1979.
13. GOEBEL, W.M.; ALLEN, G. & RANDALL, F. - The effect of commercial vasoconstrictor preparations on the circulating venous serum levei of mepivacaine and lidocaine. J. oral Med., 35:91-6, 1980.
14. HOLROYD, S.V. & WATTS, D.T. - Production of edema in rats by local anesthetics. J. dento Res., 42: 686-92, 1963.
15. HUEBSCH, R.F. - Clinical and histological study of alveolar osteitis. J. oral Surg., 16: 47382, 1958.
16. JENSEN, J .0. - Alveolar osteitis (dry socket) a review. Aust. dento J., 23: 159-63, 1978.
17. KONOW, L.V.; NORD, C.E. & NORDERAM, A. - Anaerobic Bacteria in dento alveolar infections. Int. J. oral Surg., 10: 313-22, 1981.
18. KROG, H.W. - Incidenceofdrysocket. J. amo dento Ass., 24: 1829,1937.
19. LILLY, G.E.; OSBON, D.B.; RAEL, E.M.; SAMUELS, H.S. & JONES, J.c. - Alveolar osteitis associated with mandibular third molar extractions. J. amo dento Ass., 88: 802-6, 1974.
20. MAGALHÃES, A.E.O. - Influência da fratura da crista óssea alveolar no processo de reparo em feridas de extração dental. Estudo histológico em ratos. Fac. Odont. Bauru, USP, 1979. (Tese - Mestrado).
21. MEAD, S.V.; CORRERA, O.G. & ROSADO, A.I. - Cirurgia Bucal. 2. ed. México, UTEHA, 1948. v.3.
22. MEYER, R.A. - Effect of anesthesia on the incidence of alveolar osteitis. J. oral Surg., 29: 724-6, 1971.
23. NEDER, A.C. - Farmacoterapia para cirurgiões dentistas. 5. ed. Piracicaba, 1976.
24. ROOD, J.P. & DANFORD, M. - Metronidazole in the treatment of "dry socket". lnt. J. oraISurg., 10:345-7, 1981.
25. ROZANIS, J.; SCHOFIELD, I. & KOGON, S.L. - Simulated dry socket: delayed healing of extraction wounds in rats. J. canad. dento Ass., 42:41-5,1976.
26. SAAD NETO, M.; OKAMOTO, T.; CALLESTINI, E.A. & CARVALHO, A.C.P. - Influência da irrigação do alvéolo dentário com anestésicos locais, na cronologia do processo de reparo em feridas de extração dental. Estudo histológico em ratos. Rev. Ass. paul. Cirurg. Dent., 36:606-16,1982.
27. SATIROV, S.M.; KONSTANTINOV, D.K. & GAYDADJIEV, C.A. - The effect of local anesthetics and traumas on the angiographic picture of the mandibular vessels in the cat. Oral Res. Abst.• 13:949, 1978.
28. SCHIMIDT, R.M. & ROSENKRANZ, H.S. Antimicrobial activity of local anesthetics: Lidocaine and procaine. J. inf. Diseases, 121: 597-607, 1970.
29. SHAFER, W.G.; HINE, M.K. & LEVY, B.M. - Patologia Bucal. Trad. Horacio Martinez. Buenos Aires, Mundi, 1959.
30. SODER, P.-O. - Proteolytic activity of dental plaque material Part IV. Lysis of haemoglobin, amino-acid esters and synthetic poly-aminoacido Odont. T., 75: 1-16, 1967. ApudBIRN, H. - Bacteria and fibrinolytic activity in dry socket. Acta odont. scand., 28: 773-83, 1970.
31. STEADMAN, F.SU. - Anestesia local en odontologia. Trad. Vila y Torrent. Barcelona, Pubul, 1929.
32. SVEEN, K. - Effect of the addition of a vasoconstrictor to local anesthetic solution and operative and postoperative bleeding, analgesia and wound healing. lnt. J. oral Surg., 8: 301-6, 1972.
33. THOMA, K.H. - Cirurgia bucal. México, UTEHA,1955.
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