Processo de reparo em feridas de extração dental em ratos submetidos à ação da difenil-hidantoína sódica. Estudo histológico
Effect of sodium difenylhydantoinate ou dental alveolar wound healing in rats. Histological study
Bogarin-Rodrigues, J.E.; Castro, A.L.; Matheus, G.
Rev. odontol. UNESP, vol.11, nÚnico, p.73-79, 1982
Resumo
Os autores estudam o processo de reparo de extração dental de ratos submetidos a administração de 35 mg/kg de peso de difenil-hidantoína sódica (EPELIN), via intraperitonial. Decorridos 3,6,9,12,18 e 21 dias após a exodontia, os animais foram sacrificados tendo sido as peças obtidas processadas rotineiramente para o estudo histológico, o qual revelou que nos animais injetados ocorreu intensa fibrogênese na fase inicial e intermediária do processo de reparo alveolar o retardo na deposição de matriz óssea, culminando com atraso na formação e mineralização das trabéculas ósseas, na fase final da reparação.
Palavras-chave
Processo de reparo alveolar, difenil-hidantoína sódica
Abstract
The authors studied histologically the effect of sodium difenyl-hydantoinate on dental alveolar wound healing in rats. The drug administration was by intraperitoneal via and the animals were sacrificed at 3, 6, 9, 12, 18 and 21 days after exodonta. The pieces were got by dissection and processed by routine methods. The results showed a heavy fibrogenesis in the early and intermediary stage of the alveolar wound healing process an in the last stage, delay in the bone matrix deposition, trabeculae formation and mineralization.
Keywords
Processo de reparo alveolar, difenil-hidantoína sódica
References
BHUSSRY, B.R. & RAO, S. 1963. Effect of sodium difenyl-hydantoinate on oral mucosa of rat. P.S.E.B.M,113:595-599.
BOUILLON, R., REINAERT, l., CLAES, l.H., LISSENS, W. & DE-MOOR, P. 1975. The effect of anticonvulsant therapy on serun leveis of 25 Hidroxi- Vitamin, D, Calcium and parathyroide hormone. J. elin. Endocrino1. Metab., 41:1130-1135.
CHRISTIANSEN, C., KRISTENSEN, M. & RODBRO, P. 1972. Latent osteomalasia in epileptic patients on anticonvulsants. Brit. medo J., 3:738-739.
CROSLEY, C.L, CHEE, C. & BERMAN, P. 1975. Rickets associated with long-term anticonvulsant therapy in a pediatric outpatient population. Pediatrics, 56: 52-57.
DENT, C.E. RICHENS, A., ROWE, D.S.F. & STAMP, T.C.B. 1970. Osteomalacia with long term anticonvulsant therapy in epilepsy. Brit. medo J., 4:69-72.
DILL, R.E. 1966. Discrepancy of adrenal'response in diphenylhydantoin treated rats. Arch. int. Pharmacodyn., 160:363-372.
GENUTH, S.M., KLEIN, L., RABINOVICH, S. &, KING, K.C. 1972. Osteomalasia accompanying chronic anticonvulsant therapy. J. elin. Endocrinojo Metab., 35: 378-386.
HARRIS, M. ROWE, D.LF. & DARBY, A.l. 1978. Anticonvulsant osteomalacia induced in the rat by diphenylhydantoin. Calei! Tiss. Res., 25:13-17.
HASSEL, M.T., PAGE, R.C. NARAYANAN, A.S. & COOPER., C.G. 1976. Diphenylhydantoin (Dilantin) gingival hiperplasia: Drug-induced abnormaIity of conective tissue. Proc. natJ. Acad. Sei., 73:2909-2912.
HUNTER, l., MAXWEL, J.D., STEWAR, D.A. PARSONS, V. & WILLIANS, R. 1971. Altered calcium metabolism in epileptic children on anticonvulsants. Brit. Med. J., 4:202-204.
MEDLINSKI. H.L. 1974. Rickets associated with anticonvulsant medication. Pediatrics, 53: 91-95.
MOSEKILDE, L. & MELSEN, F. 1976. Anticonvulsant osteomalasia determined by quantitative analysis of bone changes. Acta. medo Scand., 199:349-355.
NEASE, W.L 1965. Effect of sodium diphenylhydantoinate on tissue cultures of human gingival J. Periodont, 36:22-33.
OKAMOTO, T. & RUSSO, M.C. 1973. Wound healing following tooth extraction. Rev. Fac. Odont. Araçatuba, 2:153-168.
RODBRO, C., CHRISTIANSEN, C. & LUND, M. 1974. Development of anticonvulsant osteomalacia epitelic patients on pheny toin treatment. Acta. neurol. Scand., 50:527-532.
SANCHEZ, M.G., OKAMOTO, T. & CARVALHO, A.C.P. 1975. Efeitos da prednisolona no processo de reparo em feridas e extração dental. Estudo histológico. Rev. Fac. Odont. Araçatuba, 4: 195:203.
SKLANDS, S., TAYLOR, G. & SHKLAR, G. 1967. Effect of diphenylhydantoin sodium on healing of experimentally produced fractured in rabbit mandibles. J. oral Surg., 25:310-319.
SONI, N.N., SILBERKWEIT, M., STRICKER, E. & SALAMAT, K. 1967. Mitotic activity in human gingival epitelium associated with dilantin sodium therapy.Periodont, 5: 70-72.
SOTANIEMI, E.A., HAKKARAINEN, H.K., PURANEN, J.A., & LAMTI, R. 1972. Radiologic bone chances and hipocalcemia with anticonvulsant therapy in epilepsy. Ann. int. Med., 77:389-394.
TAUBENHAUS, M., TAYLOR B &. MORTON, LV. 1958. Endocrinology. 51: 183. Apud ASBOEHANSEN, G. 1963. Hormonal effects of conective tissue. Physio1. Rev., 38:446-462.
VITTEK, l., GORDON, G.C., RAPPAPORT, S.C. & SOUTHREN, 1. 1979. Cellular regulation of the metabolism of androgens in rat oral mucosa. III activation of t:. 4 - 3 - ketosteroid - 5 Cl' Aring reductase enzime sistem by 5,5 - diphenylhydantoin. J. dent. Res., 58:642-645.
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