Revista de Odontologia da UNESP
Revista de Odontologia da UNESP
Original Article

Effect of glutamine ingestion on the progression of induced periodontitis: experimental study in rats

Efeito da ingestão de glutamina na progressão de periodontite induzida: estudo experimental em ratos

Aurélio Rosa da SILVA JUNIOR; Alex SEMENOFF SEGUNDO; Tereza Aparecida Delle Vedove SEMENOFF; Natalino Francisco da SILVA; Cervantes CAPOROSSI

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Abstract: Introduction: With glutamine supplementation there is better performance in the body’s defense system.

Objective: The aim of this study was to analyze the effect of glutamine supplementation on ligand-induced periodontal disease in rats.

Material and method: 48 selected male Wistar rats were divided into 4 groups (N = 12): control group (CG) including healthy animals receiving daily saline solution via gavage; glutamine group (GG) including healthy animals receiving oral glutamine supplementation by gavage at a dose of 1.5 g / kg / day; periodontitis group (PG) including animals with induced periodontal disease on both upper sides receiving daily saline solution via gavage; experimental group (EG) including animals with induced periodontal disease on both upper sides receiving daily glutamine via gavage at a dose of 1.5 g / kg / day. On the 30th day, all animals were euthanized by excess anesthetic.

Result: In the various analyses, the EG (116.63 ± 22.50 mm2) compared to the CG (82.32 ± 7.48 mm2) obtained a p<0.05. The PG (143.15 ± 35.24 mm2) compared to the EG group (116.63 ± 22.50 mm2 ) presented a p<0.05. The PG (143.15 ± 35.24 mm2) compared to the CG (82.32 ± 7.48 mm2) presented a p<0.05. The GG (118.09 ± 10.4 mm2) compared to the CG (82.32 ± 7.48 mm2) presented a p>0.05.

Conclusion: Glutamine supplementation associated with induced periodontal disease demonstrated a smaller amount of bone loss compared to the periodontitis group.


Dietary supplements, periodontal diseases, products with antimicrobial action


Resumo: Introdução: Com a suplementação de glutamina há um melhor desempenho no sistema de defesa do corpo.

Objetivo: O objetivo deste estudo foi analisar o efeito da suplementação de glutamina na doença periodontal induzida por ligatura em ratos.

Material e método: Foram selecionados 48 ratos machos da linhagem Wistar divididos em 4 grupos (N = 12): grupo controle (GC) incluindo animais saudaveis recebendo solução salina diariamente via gavagem; grupo glutamina (GG) incluindo animais saudaveis que receberam suplementação oral de glutamina por gavagem a uma dose de 1,5 g/kg/dia; grupo periodontite (GP) incluindo animais com doença periodontal induzida na maxila em ambos os lados recebendo solução salina diária via gavagem; grupo experimental (GE) incluindo animais com doença periodontal induzida na maxila nos dois lados recebendo glutamina diária via gavagem na dose de 1,5 g/kg/dia. No 30º dia, todos os animais foram eutanasiados por excesso de anestésico.

Resultado: Nas várias análises, o GE (116,63 ± 22,50 mm2) comparado ao GC (82,32 ± 7,48 mm2) obteve um p<0,05. O GP (143,15 ± 35,24 mm2) comparado ao grupo GE (116,63 ± 22,50 mm2) apresentou p<0,05. O GP (143,15 ± 35,24 mm2) comparado ao GC (82,32 ± 7,48 mm2) apresentou p<0,05. O GG (118,09 ± 10,4 mm2 ) comparado ao GC (82,32 ± 7,48 mm2) apresentou p>0,05.

Conclusão: A suplementação de glutamina associada à doença periodontal induzida demonstrou uma menor perda óssea em comparação com o grupo periodontite.


Suplementos nutricionais, doenças periodontais, produtos com ação antimicrobiana


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