Revista de Odontologia da UNESP
https://revodontolunesp.com.br/article/588018087f8c9d0a098b4a35
Revista de Odontologia da UNESP
Review Article

Papilomavírus humano e câncer oral: uma revisão dos conceitos atuais

Human Papilomavirus and oral cancer: a review of actual concepts

Pereira, K.M.A.; Santos, P.P.A.; Rocha, D.A.P.; Lima, K.C.

Downloads: 4
Views: 1145

Resumo

Diversos fatores etiológicos estão envolvidos na etiologia do carcinoma epidermóide oral, e dentre estes, o Papilomavírus Humano (HPV) tem sido extensivamente estudado nos últimos anos. O HPV é um vírus de DNA, epiteliotrópico, cujas propriedades oncogênicas estão relacionadas a interferências nos mecanismos que controlam a proliferação celular normal. Esses mecanismos são alterados principalmente pelas proteínas E6 e E7, que interferem nas funções normais das proteínas p53 e pRb, respectivamente. Os estudos envolvendo o HPV na carcinogênese oral são controversos. Assim, a associação entre esse vírus e o câncer oral ainda não está bem definida. O objetivo desse trabalho foi realizar uma revisão literária dos aspectos atuais relacionados ao HPV no câncer oral.

Palavras-chave

Câncer oral, HPV, p53.

Abstract

Some etiologic factors are related to oral squamous cell carcinoma, and, amongst these, the Human Papillomavirus (HPV) has been extensively studied in these last years. HPV is a epitheliotropic virus of DNA, and the role of HPV in carcinogenesis is supported by its capacity of interference in important mechanisms that control the cell cycle and cellular proliferation. These mechanisms are modified mainly by the proteins E6 and E7, that intervene with the normal functions of proteins p53 and pRb, respectively. The studies involving the HPV in oral carcinogenesis are controversial. Thus, the association between this virus and the oral cancer is not still very defined. The objective of this work was to carry through a literary revision of the related current aspects to the HPV in the oral cancer.

Keywords

Oral cancer, HPV, p53

References

 


1. Brasil. Ministério da Saúde. Instituto Nacional de Câncer. Câncer de boca [citado 2006 Abril 18]. Disponível em: http://www.inca.gov.br.

2. Moore SR, Johnson NW, Pierce AM, Wilson DF. The epidemiology of mouth cancer: a review of global incidence. Oral Dis. 2000;6:65-74.

3. Nagpal JK, Bibhu RD. Oral cancer: reviewing the present understanding of its molecular mechanism and exploring the future directions for its effective management. Oral Oncol. 2003;39:213-21.

4. Scully C. Oral cancer; evidence for sexual transmission. Br Dent J. 2005;199:203-7.

5. Souza A, Stevax OM, Santos GG, Marcucci G. Epidemiologia do carcinoma epidermóide da mucosa bucal – contribuição ao estudo sobre três variáveis: sexo, faixa etária e raça. Rev Odonto Unicid. 1996;8:127-34.

6. Landis HS, Murray T, Bolden S, Wingo PA. Cancer statistics 1999. CA Cancer J Clin. 1999;49(1):8-31.

7. Silverman Jr S, Sugerman PB. Oral premalignancies and squamous cell carcinoma. Clin Dermatol. 2000;18:536-8.

8. Bungaard T, Bentzen SM, Segaard H. Histological differentiation of oral squamous cell cancer in relation to tobacco smoking. Eur J Cancer B Oral Oncol. 1995;31B:118-21.

9. Neville BW, Damm DD, Allen CM, Bouquot JE. Patologia epitelial. In: Neville BW, Damm DD, Allen CM, Bouquot JE. Patologia oral & maxilofacial. 2a ed. Rio de Janeiro: Guanabara Koogan; 2004. p. 303-72.

10. Wight AJ, Ogden GR. Possible mechanisms by which alcohol may influence the development of oral cancer – a review. Oral Oncol. 1998;34:441-7.

11. Miller CS, Johnstone BM. Human papillomavirus as a risk for oral squamous cell carcinoma: a meta-analysis, 1982-1997. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91:622-35.

12. Soares CP, Malavazi I, Reis RI, Neves KA, Zuanon JAS, Benatii Neto C, et al. Presença do papilomavirus humano em lesões malignas de mucosa oral. Rev Soc Bras Med Trop. 2002;35:439-44.

13. Sugiyama M, Bhawal UK, Dohmen T, Dohmen T, Ono S, Miyauchen M, et al. Detection of human papillimavirus-16 and HPV-18 in normal, dysplastic, and malingnant oral epithelium. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;95:594-600.

14. Wight AJ, Ogden GR. Possible mechanisms by which alcohol may influence the development of oral cancer – a review. Oral Oncol. 1998;34:441-7.

15. Azzimonti B, Hertel L, Aluffi P, Pia F, Monga G, Zocchi M, et al. Demonstration of multiple HPV types in laryngeal premalignant lesions using polymerase chain reaction and immunohistochemistry. J Med Virol. 1999;59:110-6.

16. Oliveira MC, Andrade MC, Soares RC, Costa ALL. Aspectos morfológicos que sugerem a presença do papilomavírus humano (HPV) em lesões do epitélio de revestimento da mucosa oral. Rev Bras Patol Oral. 2003;2(2):34-43.

17. Zur Hausen H. Papillomavirus infection- a major cause of human cancers. Bioch Biophy Acta. 1996;1288:F55‑F78.

18. Bouda M, GorgouliS VG, Kastrinakis NG, Giannoudi SA, Tsoli E, Danassi-Afentaki D, et al. “High risk” HPV type are frequently detected in potentially malignant and a malignant oral lesions, but not in normal oral mucosa. Mod Pathol. 2000;13:644-53.

19. Giovannelli L, Campisi G, Lama A, Giambalvo O, Osborn J, Margiotta V, Ammatuna P. Human papillomavirus DNA in oral mucosal lesions. J Infect Dis. 2002;185:833-6.

20. Syrjänen S. Human papilomavírus (HPV) in head and neck cancer. J Clin Virol. 2005;32S:S59-S66.

21. Tang X, Jia L, Ouyang J, Takagi M. Comparative study of HPV prevalence in Japanese and North-east Chinese Oral Carcinoma. J Oral Pathol Med. 2003;32:393-8.

22. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Biologia molecular da célula. 4ª ed. Porto Alegre: Artmed; 2004.

23. Scully C. Oral squamous cell carcinoma: from an hypothesis about a virus, to concern about possible sexual transmission. Oral Oncol. 2002;38:227-34.

24. Sugerman PB, Shillitoe EJ. The high risk human papillomaviruses and oral câncer; evidence for and against a causal relationship. Oral Dis. 1997;3:130-47.

25. Summersgill KF, Smith EM, Levy BT, Kirchner L, Hausen TH, Turek LP. Human papillomavirus in the oral cavities of children and adolescents. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91:62-9.

26. Terai M, Takagi M. Human papillomavirus in the oral cavity. J Oral Med Pathol. 2001;6:1-12.

27. Villa LL. Human papillomaviruses and cervical cancer. Adv Canc Res. 1997;71:321-41.

28. Zur Hausen H. Papillomaviruses causing cancer: evasion from host-cell control in early events in carcinogenesis. J Natl Canc Inst. 2000;92:690-8.

29. McMurray HR, Nguyen D, Westbrook TF, McAnce DJ. Biology of human papillomaviruses. Int J Exp Pathol. 2001;82:15-33.

30. De Villiers EM. Heterogeneity of the human papillomavirus group. J Virol. 1989;63: 4898-903.

31. Culp TD, Christensen ND. Kinetics of in vitro adsorption and entry of papillomavirus virions. Virology. 2004;319:125-61.

32. Giroglou T, Florin L, Schafer F, Streeck RE, Sapp M. Human papillomavirus infection requires cell surfaces heparin sulfate. J Virol. 2001;75:1565-70.

33. Kojima A, Maeda H, Kurahashi N, Tanaka S, Kameyama Y. Human papillomaviruses in the normal oral cavity of children in Japan. Oral Oncol. 2003;39:821-8.

34. Terai M, Takagi M, Matsukura T, Sata T. Oral wart associated with human papillomavirus type 2. J Oral Pathol Med. 1999;28:137-40.

35. Zhang ZY, Sdek P, Cao J, Chen WT. Human papillomavirus type 16 and 18 in oral squamous cell carcinoma and normal mucosa. J Oral Maxillofac Surg. 2004;33:71-4.

36. Kumar V, Abbas AK, Fausto, N. Robbins e Cotran. Patologia – bases patológicas das doenças. 7a ed. Rio de Janeiro: Guanabara Koogan; 2005. p. 281-356.

37. Soares CP. Papilomavírus humano (HPV) – um estudo de revisão. Rev Ciênc Farm. 1999;20:11-34.

38. Doorbar J. The papillomavirus life cycle. J Clin Virol. 2005;32S: S7-S15.

39. Thomson CB. Apoptosis in the patogenesis and treatment of diseases. Science. 1995;267:1456-62.

40. Weinberg RA. E2F and cell proliferation: a world turned upside down. Cell. 1996;85:457-9.

41. Major T, Szarka K, Sziklai I, Gergely L, Czegledy J. The characteristics of human papilomavírus DNA in head and neck cancers and papillomas. J Clin Pathol. 2005;58:51-5

42. Tinoco JA, Silva AF, Oliveira CAB, Rapoport A, Fava AS, Souza RP. Correlação da infecção viral pelo papilomavirus humano com as lesões papilomatosas e o carcinoma epidermóide na boca e orofaringe. Rev Assoc Med Bras. 2004;50:252-6.

43. Fernandes JV, Meissner RV, Fernandes TAAM, Rocha LRM, Cabral MC, Villa LL. Comparação de três protocolos de extração de DNA a partir de tecido fixado em formol e incluído em parafina. J Bras Patol Med Lab. 2004;40:141-6.

44. Vidal AKL, Caldas Júnior AF, Mello RJV, Brandao VRA, Rocha GI, Taromaru E. HPV detections in oral carcinomas. J Bras Patol Med Lab. 2004;40:21-6.

 

588018087f8c9d0a098b4a35 rou Articles
Links & Downloads

Rev. odontol. UNESP

Share this page
Page Sections