Revista de Odontologia da UNESP
https://revodontolunesp.com.br/article/588017de7f8c9d0a098b4951
Revista de Odontologia da UNESP
Original Article

A participação das metaloproteinases da matriz nos processos fisiopatológicos da cavidade bucal

The participation of matrix metalloproteinases in the physiopathological processes of the oral cavity

Navarro, V.P.; Nelson Filho, P.; Silva, L.A.B.; Freitas, A.C.

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Resumo

Metaloproteinases da Matriz (MMPs) são um importante grupo de enzimas proteolíticas zinco-dependentes responsáveis pela degradação de matriz extracelular e membranas basais. As enzimas são secretadas em uma forma latente e se tornam ativadas no ambiente pericelular, sendo relacionadas a processos fisiológicos e patológicos na área odontológica. No presente estudo, foram revisados alguns aspectos importantes das MMPs, discutindo-se o papel dessas enzimas em processos fisiológicos como o início da mineralização dentinária, a remodelação do colágeno dos tecidos periodontais e o processo de erupção, entre outros. Dentre os processos patológicos que acometem a cavidade bucal e envolvem a participação das MMPs, destacam-se a destruição tecidual periodontal, as lesões de cárie radicular, as metástases em alguns tipos de tumores e as desordens da articulação temporomandibular.

Palavras-chave

Metaloproteinases da matriz, boca

Abstract

Matrix metalloproteinases (MMPs) are an important group of zinc-dependent proteolytic enzymes that mediate the extracellular matrix and basement membrane degradation. The enzymes are secreted in latent form and become activated in the pericellular environment and have been related with physiological and pathologic oral process. In the present work we review some important aspects of matrix metalloproteinases, and discuss the role of these enzymes in the normal physiological process like the role of MMPs in the beginning of the teeth mineralization, collagen remodeling in the periodontal tissues, eruption process, and others. In the oral pathological processes, we have the periodontal tissue destruction, root caries, metastasis in some kind of tumors and disorders of the temporomandibular join.

Keywords

Matrix metalloproteinases, mouth

References



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